Recovery from Covid

Covid Recovery 5th Sep 2021– Dr Lalith Mendis

  1. After hospital discharge – Watch oxygen saturation & pulse rate for further 7 days – at least
  2. Ivermectin 12 mg daily for 5 days may help long covid syndromes. (thereafter 12 mg every other week)
  3. While on bed even in the early days – tighten your calf, thigh muscles, attempt to write letters with your big toe – this helps venous circulation & prevents thrombosis
  4. If pulse rate is high – it may be ‘cos dehydration; drink enough Jeevanie esp after diarrhea
  5.  Incipient hypoxia also causes high pulse rate
  6. After triple therapy (with dexamethasone) in hospital, you may get gastritis – Gaviscon syrup has to be prescribed
  7. DO NOT RETURN TO VIGOROUS EXERCISE OR WORK

Lung Repair

  • Physician may continue antibiotics & dexamethazone at home for few days.
  • Bromhexine syrup can help in lung resolution. 10 ml bd
  • Deriphyllin & other agents given for lung recovery can alter sleep rhythm & increase stress
  • Physician may continue – Budesonide 2 puffs (each puff 200 mcg) bd
  • Famotidine 20 my bd was found useful to reduce lung involvement
  • Fenfibrate was found useful to resolve immune lung complications (ask dr. do not self medicate with prescription drugs.)

Rest, Sleep

  1. Absolute bed rest even after coming home at least for 10 days – if your lung was involved.
  2. Restore sleep awake rhythm. Reduce LED screen & lights.
  3. Prayers, song, cheery atmosphere, others reading to you – will be helpful for recovery.
  4. With moderate or severe lung involvement – one month rest. Follow up by Physician is needed
  5. Sweating, pulse rate – may indicate altered metabolic rate. Will need review. Anxiolytic sedatives

Neutriceticals

  1. Regular cinnamon tea (not with statins), cloves
  2.  Continue vit D, Zinc, Vit A
  3. Lots of tea (quercetin), toast with mustard
  4. Onions, kaluduru,sooduru, ginger – brew like rasam. (supported by research)
  5. Omega 3 fish oil capsules help in immunity rebuilding
  6. Big bowl of pineapple, apple, pera, onions.
  7. Add garlic curry to your diet. Kottamalli bd also. Legumin protein in dhal was found to be helpful. Egg & fish are recommended

After Care

  • Family members Ivermectin prevention 12 mg bd for 5 days
  • PCR positive above Ct 32 may indicate post convalescent status – Rapid antigen should be negative. You are not infective.
  • This article does not discuss many long term covid complications that have been documented.   

Fifteen Long Covid Syndromes

Long Covid Syndromes

Index

  1. Immune Pathogenesis caused by ACE 2 antibodies producing high levels of Angiotenin II
  2. Immune Pathogenesis & IFN
  3. Continuing Neutrophil & other inflammatory activity in the Lung
  4. Metabolically hyperactive Immune Cells
  5. Neurological Issues
  6. Hypopituitarism
  7. Worsen Diabetes
  8. Give Vit K to prevent breakdrown of elastic tissues in the lung
  9. Neurological Issues
  10. Long Term Kidney Diseases
  11. Reversing Lung Fibrosis in Covid
  12. Fibromyalgia in Long Covid
  13. Abnormal Neutrophils in Lungs
  14. Continued Lung Endotheliopathy
  15. Female Fertility
  16. 16 Covid Myocarditis

Long Covid Syndromes

  1. Immune Pathogenesis caused by ACE 2 antibodies producing high levels of Angiotenin II University of Arkansas Discovers Unique ACE-2 Targeting Antibody That Appears Weeks After COVID-19 As Main Cause Of LONG COVID! Aspirin long term will prevent sudden thrombosis

“Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) commonly, referred to as Long COVID, but the specific mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and decreased immune system activation.
 
The study team hypothesized that autoantibodies against ACE2 may develop after SARS-CoV-2 infection, as anti-idiotypic antibodies to anti-spike protein antibodies. These study findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which causes a proinflammatory state that triggers symptoms of PASC.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257016

Possible treatment = AT 1 block (Losartan) = AT2 stimulation = MAS Ang (1-7) action – bradykinin, NO release, reduce TNF alpha, increase TNF gamma, resolution

University of Arkansas Discovers Unique ACE-2 Targeting Antibody That Appears Weeks After COVID-19 As Main Cause Of LONG COVID!

“Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) commonly, referred to as Long COVID, but the specific mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of the AT1 receptor and decreased immune system activation.
 
The study team hypothesized that autoantibodies against ACE2 may develop after SARS-CoV-2 infection, as anti-idiotypic antibodies to anti-spike protein antibodies. These study findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which causes a proinflammatory state that triggers symptoms of PASC.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257016

Possible treatment = AT 1 block (Losartan) = AT2 stimulation = MAS Ang (1-7) action – bradykinin, NO release, reduce TNF alpha, increase TNF gamma, resolution

  • Immune Pathogenesis & IFN – Chinese scientist from Shandong University in Jinan-China have discovered that the SARS-CoV-2 ORF9b  proteins  are able to inhibit type I and III interferon (IFN) response and production by targeting various components of various immune signaling pathways. According to the study findings, the SARS-CoV-2 ORF9b proteins impaired the induction of type I and III IFNs by Sendai virus or the dsRNA mimic poly (I:C).

It was found that the SARS-CoV-2 ORF9b proteins inhibits the activation of type I and III IFNs induced by the components of cytosolic dsRNA-sensing pathways of RIG-I/MDA5-MAVS signaling, including RIG-I, MDA-5, MAVS, TBK1, and IKKε rather than IRF3-5D, the active form of IRF3.

https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.27050
 n

  • Continuing Neutrophil & other inflammatory activity in the Lung – A new breakthrough study by scientist from New York University Grossman School of Medicine has found SARS-CoV-2 induced hyperactive platelets’ unique genes S1000A8 and  S1000A9 causes the platelets to produce more myeloid-related proteins (MRP) 8 and 14 that contribute to increased inflammation, clotting, disease severity and longer hospital stays. The study also showed that drugs known to block platelet activation via the platelet surface protein P2Y12 (clopidogrel or ticagrelor) reduced COVID-19-related inflammation in vessels.

https://www.science.org/doi/10.1126/sciadv.abh2434

  • Metabolically hyperactive Immune Cells – The team documented the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.

https://www.nature.com/articles/s41587-021-01020-4

 For example, among CD8+ and CD4+ T cells, metabolic activation corresponding with COVID-19 severity was driven by small, metabolically hyperactive subpopulations not identifiable through analyses of averaged behavior. Similar trends were also observed for B cells, NK cells and monocytes. For monocytes, the team documented metabolic changes between two diverging subpopulations. Inflammatory monocytes increased in number and metabolic activity per cell, while non-classical monocytes behaved oppositely in both respects. These changes occurred not only during the initial polarization of monocytes to these phenotypes as previously reported but also continuously along the spectrum of disease severity.
 “We have found metabolic reprogramming that is highly specific to individual immune cell classes (e.g. “killer” CD8+ T cells, “helper” CD4+ T cells, antibody-secreting B cells, etc.) and even cell subtypes, and the complex metabolic reprogramming of the immune system is associated with the plasma global metabolome and are predictive of disease severity and even patient death.

  • Neurological Issues

Spike proteins of the SARS-CoV-2 coronavirus have a strong biding affinity for the enzyme found in the brain called monoamine oxidases (MAO) enzymes and it is as a result of these binding and subsequent disruption in the various neurotransmitters activities and chemical pathways that a various of neurological conditions emerge including neurodegenerative conditions that can result in Parkinson’s or Alzheimer’s disease! Even more worrisome was the fact that the study found that certain emerging variants such as the South African Beta variant because of the Spike mutations, have an even greater enhanced affinity of binding to these monoamine oxidases (MAO) enzymes.

Many published research agrees that COVID-19 is likely to have long-term mental health effects on infected individuals, which signifies a need to understand the role of the virus in the pathophysiology of brain disorders that is currently unknown and widely debated.
 The study team’s docking and molecular dynamic simulations show that the affinity of the spike protein from the wild type (WT) and the South African B.1.351 (SA) variant towards the MAO enzymes is comparable to that for its ACE2 receptor. This allows for the WT/SA…MAO complex formation, which changes MAO affinities for their neurotransmitter substrates, thus consequently impacting the rates of their metabolic conversion and misbalancing their levels.

https://www.biorxiv.org/content/10.1101/2021.08.30.458208v1

Surprisingly it was found that in the Beta variant, all three of its spike protein mutations promote MAO-A binding. The mutated Asn417 residue appears to contribute the most to the binding of MAO-A, which could indicate the formation of a SARS-CoV-2 beta variant–MAO-A complex.
 
Furthermore two spike protein residues in the Beta variant, S-Leu455 and the mutated Asn417, use their backbone carbonyl and side-chain amide atoms to engage with MAO A’s Arg297 residue. The SARS0CoV-2 virus’s impact on MAO’s binding to other substrates is affected even further with the Beta variant. The Beta variant increases MAO affinity towards its substrates and induces higher rates of metabolic degradation, resulting in their depletion.

Fluvoxamine can help in this

  • Hypopituitarism – SARS-CoV-2 coronavirus is able to affect the human host pituitary gland and possibly cause hypopituitarism and also a variety of pituitary gland abnormalities and disorders along with disrupting various metabolic functions. The study also found that existing pituitary gland disorders and existing hypopituitarism prior to SARS-CoV-2 infections can also aggravate COVID-19 outcomes including disease severity and increased risk of mortality. Furthermore the condition of hypopituitarism is frequently burdened by several metabolic complications, including arterial hypertension, hyperglycemia, obesity and vertebral fractures, which have all been associated with poor outcomes and increased mortality in patients infected by SARS-CoV-2.
     https://rd.springer.com/article/10.1007/s11154-021-09672-y
    The study findings report hypopituitarism as a condition that might have a bidirectional relationship with COVID-19 due to the frequent presence of metabolic comorbidities, to the direct or indirect pituitary damage or being per se a potential risk factor for COVID-19.
     At the same time, researchers have also observed that COVID-19 causes increased severity of pituitary-related disorders, and even pituitary apoplexy, which is a condition defined as internal bleeding or impaired blood supply in the pituitary gland. https://pubmed.ncbi.nlm.nih.gov/33939057/
     
  • Worsen Diabetes – Hence, SARS-CoV-2 binding to these ACE2 receptors facilitates the entry of this virus into all the organs that have these receptors, thus leading to the ability of SARS-CoV-2 to cause widespread damage in the body. Upon entry into the pancreas, for example, SARS-CoV-2 can inhibit ß-cells function, which worsens hyperglycemia and increases the risk for acute diabetic complications.
  • Give Vit K to prevent breakdrown of elastic tissues in the lung. That Lack Of Sufficient Vitamin K Plays A Role In COVID-19 In Terms Of Lung Damage And Thromboembolism. A new study by medical researchers from Canisius-Wilhelmina Hospital-Netherlands, Maastricht University-Netherlands and also involving doctors from University Hospitals Leuven-Belgium has found that Vitamin K play a critical role in preventing COVID-19 disease severity especially involving lung damage and thromboembolism.

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/vitamin-k-metabolism-as-the-potential-missing-link-between-lung-damage-and-thromboembolism-in-coronavirus-disease-2019/C3E7267D0D19B048E1D8AB9D83754CFC

Importantly the matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation.
 Vitamin K-dependent matrix Gla protein (MGP) has been extensively studied as an inhibitor of vascular mineralization; however, its role in the pulmonary compartment seems to be comparable. Besides preventing soft tissue calcification, MGP also protects against elastic fibre degradation. This was demonstrated in MGP knockout mice, which developed severely mineralized as well as fragmented elastic fibres. Severe extrahepatic vitamin K insufficiency was recently demonstrated in COVID-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates.

These findings suggest that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2-induced proteolysis. In contrast to MGP, COVID-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors.
 
The study team also expects that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity. Collectively these data has lead the study team to propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively.
 
The study team proposes that intervention trials should be conducted to assess whether vitamin K administration  as COVID-19 Supplements plays a role in the prevention and treatment of severe COVID-19.

  • Neurological Issues

A new study led by researchers from the University of Queensland-Australia has shockingly found that unique proteins called fusogens found on the surface of the spike proteins of the SARS-CoV-2 coronavirus is able cause the fusion of neurons cells  and also cause fusion between neurons and glial cells. This phenomena could possibly explain the various neurological manifestations in both COVID-19 and post-COVID patients.

https://www.biorxiv.org/content/10.1101/2021.09.01.458544v1

During virus replication, these fusogens decorate the host cells membrane enabling them the ability to fuse with neighboring cells, forming syncytia that the viruses use to propagate while evading the immune system. https://pubmed.ncbi.nlm.nih.gov/18496517/

Most of the current immunization approaches for COVID-19 are based on expressing the spike S protein in the host cells as an epitope to trigger the immune system response. These nucleic acid-based vaccines deliver the antigen encoded as mRNA, such as the Pfizer-BioNTech BNT162b2 and the Moderna mRNA-1273 vaccines, or as adenovirus-enclosed DNA, such as the OxfordAstraZeneca ChAdOx1 nCoV-19/AZD1222 33 and Johnson & Johnson Ad26.COV2.S vaccines.

Our findings demonstrate that it is critical to consider the fusogenic potential when designing any future vaccines in which viral fusogens are to be expressed in mammalian cells.”

  1. Long Term Kidney Diseases  A detailed deep dive into U.S.federal health data adds to those concerns, pointing to a significant decline in kidney function among those dubbed COVID-19 long-haulers and even among those who had mild infections of the virus.
     The alarming study findings showed that those infected with SARS-CoV-2 are at an increased likelihood of developing kidney damage as well as chronic and end-stage kidney diseases.
     The study findings were published in the peer reviewed Journal of the American Society of Nephrology. https://jasn.asnjournals.org/content/early/2021/08/25/ASN.2021060734
     “The risk of decreased kidney function is highest among people who were in the ICU; however, it’s important to note that the risk extends to all patients, even those who had milder cases of COVID-19.”
     
    He further added, “Earlier stages of kidney disease often can be treated with medication. It’s essential to discover kidney dysfunction before the problem progresses and becomes harder to treat. But kidney problems are silent problems that won’t be found until somebody checks the bloodwork. Based on our research, it’s especially important that health-care providers do this for people who have had COVID-19. Otherwise, we’ll miss a lot of people and, sadly, we’ll be dealing with more advanced kidney diseases down the road.”
     
    When compared with patients who did not become infected, individuals who contracted the virus but did not need to be hospitalized for it had a 15% higher risk of suffering from a major adverse kidney event such as chronic kidney disease, a 30% higher risk of developing acute kidney injury, and a 215% (more than twofold) higher risk of acquiring end-stage kidney disease.
     
  2. Reversing Lung Fibrosis in Covid – Cell Death & Bleomycin Differentiation https://www.nature.com/articles/s41418-021-00840-w Furthermore existing dogma did not point to macrophages as actors in fibrosis; it instead proposed that increased alveolar epithelial cell injury and apoptosis were the initiating events in lung fibrosis.
     
    The cellular activity called apoptosis is a regulated suicide process for cells that are a threat to the organism or are no longer needed. Mitochondria, the organelles that are the powerhouses of the cell, play a key role in the intrinsic pathway of apoptosis. The study findings suggest that fatty acid oxidation provokes apoptosis resistance through the stabilization of Bcl-2 in the mitochondria by binding to Cpt1a. Moreover, these data demonstrate that monocyte-derived macrophages are required for fibrosis progression, and they suggest a novel therapeutic target to prevent progressive aberrant fibrotic remodeling.”
     
  3. Fibromyalgia in Long Covid

A new Italian study led by the Rizzoli Orthopedic Institute and the University of Bologna that also involved researchers from the University of Catanzaro, University of Turin, Università Campus Bio-Medico di Roma and the University of Ferrara has alarming found that there is now a growing prevalence of the medical condition known as fibromyalgia among so called recovered COVID-19 patients who had been previously been infected with the various SARS-CoV-2 variants. The study findings suggest that clinical features of FM are common in patients who recovered from COVID-19 and that obesity and male gender affect the risk of developing post-COVID-19 FM.
 
The study findings were published in the peer reviewed BMJ journal: Rheumatic and Musculoskeletal Diseases. https://rmdopen.bmj.com/content/7/3/e001735

  1. Abnormal Neutrophils in Lungs The study team considers the immunosuppressive capacity of neutrophils demonstrated in the study a significant find, observed when they were isolating LDGs from the patients. When isolated in the laboratory, the cells began to secrete substances which inhibit T lymphocytes from dividing.
     
    Corresponding author Luz Cabrera added, “Low T lymphocyte levels are one of the major severity indicators for covid-19. A more effective immune response can be the difference between a milder disease and more severe one.”
  2. Continued Lung Endotheliopathy

Cinnamon tea, ivermectin

Study Shows That Microscopic Lung Damage Continues In The Recovered!
A new study shows that the persistent breathing issues that plague some COVID-19 survivors, known as “long COVID,” may be due to microscopic processes that continue to damage lungs even after the acute infection is over! https://www.medrxiv.org/content/10.1101/2021.08.10.21261834v1 Shockingly when compared to healthy volunteers, the airways of these COVID-19 survivors had higher numbers of cytotoxic lymphocytes (especially tissue resident CD8+ T cells), lactate dehydrogenase and albumin (biomarkers of cell death and barrier integrity).
 A news Irish study shows that recovered COVID-19 patients will suffer persistent endotheliopathy and is one of the contributors to the so-called Long COVID Syndrome. https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15490
To date, constant symptoms including breathlessness, fatigue and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this ‘Long COVID’ syndrome remain unknown. However, autopsy studies have highlighted the key roles played by pulmonary endotheliopathy and microvascular immunothrombosis in acute COVID-19.
 
The study team hypothesized that endothelial cell activation may be sustained in convalescent COVID-19 patients and contribute to Long COVID pathogenesis. Interestingly, thrombin generation assays revealed significantly shorter lag times (p<0.0001, 95% CI -2.57– -1.02min), increased  endogenous thrombin potential (ETP) (p=0.04, 95% CI 15–416nM/min) and peak thrombin (p<0.0001, 95% CI 39–93nM) in convalescent COVID-19 patients. These pro-thrombotic changes were independent of ongoing acute phase response or active NETosis.
 
Significantly, EC biomarkers including VWF:Ag, VWF propeptide (VWFpp) and Factor VIII (FVIII:C) were significantly elevated in convalescent COVID-19 compared to controls (p=0.004, 95% CI 0.09–0.57IU/ml; p=0.009, 95% CI 0.06–0.5IU/ml; p=0.04, 95% CI 0.03–0.44IU/ml, respectively). In addition, plasma soluble thrombomodulin (sTM) levels were significantly elevated in convalescent COVID-19 (p=0.02, 95% CI 0.01–2.7ng/ml).
 
It was found that sustained endotheliopathy was more frequent in older, comorbid patients and those requiring hospitalization. Also, both plasma VWF:Ag and VWFpp levels correlated inversely with 6-minute walk tests.

  1. Female Fertility

 The issue as to whether SARS-CoV-2 infections can affect fertility has been raised many times due the high expression of ACE2 in the female reproductive tissues, (The entry receptor for SARS-CoV-2) and the potential damage to germline (oocytes) due to the dysfunction of autophagy in COVID-19.
 
Furthermore molecular mimicry may contribute to female infertility by leading to the generation of deleterious autoantibodies, which could also participate to the onset of an autoimmune disease in infected patients.
 
The study team carried out a systematic analysis to improve the understanding of the possible effects of SARS-CoV-2 infection on female fertility using the angle of molecular mimicry as a starting point.
 
The study findings show a number of rather long linear sequences shared by the SARS-CoV-2 proteins and oogenesis-related proteins that might play a role in the production of possibly pathogenic crossreactive autoantibodies. SARS-CoV-2 spike glycoprotein was found to share 41 minimal immune determinants, i.e., pentapeptides, with 27 human proteins that relate to oogenesis, uterine receptivity, decidualization, and placentation. All the shared pentapeptides that the study team identified, with the exception of four, are also present in SARS-CoV-2 spike glycoprotein–derived epitopes that have been experimentally validated as immunoreactive.
 
The study findings were published in the peer reviewed American Journal of Reproductive Immunology.
 https://onlinelibrary.wiley.com/doi/10.1111/aji.13494
 The study team propounded three ways that SARS-CoV-2 infection can influence the reproductive system and impact fertility:
 
1) Firstly via direct action of SARS-CoV-2 on Angiotensin-converting enzyme -2 (ACE2) receptor. Angiotensin-converting enzyme -2 (ACE2) receptor plays a vital role in various physiological processes. It is present in the kidneys, heart, thyroid, adipose tissue, and the reproductive system (testis, ovaries, uterus, vagina, and placenta). ACE2 has been found to play a role in follicular development, ovulation, luteal degeneration, endometrial changes, embryo development, etc. Evidence suggests that ACE2 also has a vital role in SARS-CoV-2 pathogenesis by facilitating viral entry into host cells. It has been hypothesized that SARS-CoV-2 may act through the ACE2 receptors on the reproductive system and disrupt its functioning.
 
2) Secondly evasion of autophagy in the host cell by SARS-CoV-2 may disrupt oocyte maturity. A critical mechanism of SARS-CoV-2 pathogenesis is the evasion of the autophagic system in the host cell. Autophagy is a self-cleaning process by which a cell removes unwanted debris, malformed proteins, damaged organelles, etc. Both autophagy and oxidative stress have a role in oocyte longevity. Therefore, by disrupting autophagy in host cells, SARS-CoV-2 may impact oocyte maturation and fertility.
 
3. Thirdly via molecular mimicry between the host and SARS-CoV-2 proteins may influence fertility. The amino acid sequences in the proteins of the host cells and SARS-CoV-2 may exhibit similarities. This can result in cross-reactivity of the antibodies produced by the infected patients against SARS-CoV-2, leading to an autoimmune state where their cells are harmed. This condition is called molecular mimicry.  In earlier studies, it was observed that molecular mimicry between hepatitis B virus (HBV) proteins and myelin basic protein in mice leads to the onset of demyelinating diseases after HBV infection.
 
Significantly, molecular mimicry between SARS-CoV-2 proteins and oogenesis-associated proteins may affect reproductive function.

it was found that the peptides that occurred in both the human oogenesis-related protein and the SARS-CoV-2 spike protein are immunoreactive. It was found from the analysis that forty-one pentapeptides from SARS-CoV-2 spike protein occurred in twenty-seven human oogenesis-associated proteins. On the Immune Epitope Database, it was found that all of the matching pentapeptides except for two have been identified to be immunoreactive.
 
Hence these finding showed that COVID-19 patients may develop an autoimmune condition that can affect their fertility!
 
Importantly there exist amino acid sequence similarities between human oogenesis-associated proteins and SARS-CoV-2 spike protein which can elicit the production of cross-reactive antibodies.
 
The study team also found that during SARS-CoV-2 infection, there is a possibility of cross-reactive antibodies being produced against various proteins associated with the reproductive system. This can affect fertility and cause disruptions in the reproductive function of the infected patient.  
 
Also alarmingly some of the possible effects of cross-reactive antibodies attacking the human oogenesis-related proteins include; destruction of germ cells, reduction in the size of the testis and ovaries, alterations in the expression of genes associated with sexual dimorphism, aberrations in the reproductive function, lack of sexual maturation, etc.
 
The research team says that the study findings from the present study are preliminary and indicate a possibility that COVID-19 infected patients may develop an autoimmune condition that can affect their fertility.

  1.  

Covid Convalescence Without Complications

Covid Recovery 5th Sep 2021– Dr Lalith Mendis

  1. After hospital discharge – Watch oxygen saturation & pulse rate for further 7 days – at least
  2. Ivermectin 12 mg daily for 5 days may help long covid syndromes. (thereafter 12 mg every other week)
  3. While on bed even in the early days – tighten your calf, thigh muscles, attempt to write letters with your big toe – this helps venous circulation & prevents thrombosis
  4. If pulse rate is high – it may be ‘cos dehydration; drink enough Jeevanie esp after diarrhea
  5.  Incipient hypoxia also causes high pulse rate
  6. After triple therapy (with dexamethasone) in hospital, you may get gastritis – Gaviscon syrup has to be prescribed
  7. DO NOT RETURN TO VIGOROUS EXERCISE OR WORK

Lung Repair

  • Physician may continue antibiotics & dexamethazone at home for few days.
  • Bromhexine syrup can help in lung resolution. 10 ml bd
  • Deriphyllin & other agents given for lung recovery can alter sleep rhythm & increase stress
  • Physician may continue – Budesonide 2 puffs (each puff 200 mcg) bd
  • Famotidine 20 my bd was found useful to reduce lung involvement
  • Fenfibrate was found useful to resolve immune lung complications (ask dr. do not self medicate with prescription drugs.)

Rest, Sleep

  1. Absolute bed rest even after coming home at least for 10 days – if your lung was involved.
  2. Restore sleep awake rhythm. Reduce LED screen & lights.
  3. Prayers, song, cheery atmosphere, others reading to you – will be helpful for recovery.
  4. With moderate or severe lung involvement – one month rest. Follow up by Physician is needed
  5. Sweating, pulse rate – may indicate altered metabolic rate. Will need review. Anxiolytic sedatives

Neutriceticals

  1. Regular cinnamon tea (not with statins), cloves
  2.  Continue vit D, Zinc, Vit A
  3. Lots of tea (quercetin), toast with mustard
  4. Onions, kaluduru,sooduru, ginger – brew like rasam. (supported by research)
  5. Omega 3 fish oil capsules help in immunity rebuilding
  6. Big bowl of pineapple, apple, pera, onions.
  7. Add garlic curry to your diet. Kottamalli bd also. Legumin protein in dhal was found to be helpful. Egg & fish are recommended

After Care

  • Family members Ivermectin prevention 12 mg bd for 5 days
  • PCR positive above Ct 32 may indicate post convalescent status – Rapid antigen should be negative. You are not infective.
  • This article does not discuss many long term covid complications that have been documented.   

Septacades Panorama – How the 70 yr Periods Ran. 1740 – 2020

Septacades – 70 year periods

Forces of Disruption

 Forces of Restoration

1740 – 1810

Feudal Hegemony Failing, peasants restless, kings increasingly oppressive. Voltaire dethrones God. My of of Renaissnce of man & culture brutally busted by the French Revolution 1789 – which was the explosion. Sets stage for utopia by more blood letting – Dante executed by Robespierre.

Methodism in England – uplifting working class education, morals, spirituality. Key figure John Wesley. Likes of French Revolution prevented.

1810 – 1880

Napoleon sets the stage for European Wars. Freud, Marx, Darwin capture intellectual mindset

Theologians give up God who is near & inspiration of His word. Science becomes new god – who was, who is who will know all.

Nations in feudal systems invaded by the Colonial expansionism with good, bad & ugly consequences.

USA takes up mantle of spiritual renewal, Jonathan Edward, Founder President of Harvard,

Great innovations by pioneer scientists who believed in a Designed Universe & discoverable laws of science – applied for innovations.

Britain set sights on world conquest with carrot & stick. William Gladstone a bright spark as British PM.

Christianity becomes the invading religion.  

1880-1950

Great strides in creature comforts as Industrial revolution comes to stay, along with its class system – capital owners & labour. Land owners recede & urban rich industrialists arise. As urban poverty increases & people loose their ancestral land, urban migration & poverty &oppression increase.

Western nations lost God & their moral authority with WW I. Marxism launched their experiment of an utopia of the proletariat in Russia, amidst much blood shed.

Wars & trade set stage for future nation states. Germany demonstrated with Hitler, how a very industrialized egalitarian Bourgeoisie class, was well able to be steered into tribal megalomania.

British Colonialism makes way for missionary advance along with British education, civil service, AR/FR, Medical & legal systems. Britain rules the waves & waives the rules.

With Colonialism a new middle class of educated professionals arise – poor get a chance to educate their next generation who can rise to significant positions & could bring a in socioeconomic transformation across the board. Yet they would in the next septacade (70 yrs)  serve global dinosaur oligarchs, in a world gripped by Keynesian consumerism demand drive supply economics.

In the 1940’s locals get their nations back to govern themselves – with the good, bad & ugly consequences of Colonialism..

1950 – 1985 first half of the septacade

World was ready for recuperation after the WW II & nuclear blast. South Korea was a great example of a war ravaged country in 1956 arising to be an economic super power.

However global dinosaur oligarchs manipulate market, in a world gripped by Keynesian consumerism demand drive supply economics. Increasingly, essentials of food, clothing, shelter, health, educate get less of the GDP. Semi or non essentials dominate the market – Pharma, armament, motor, fashion, IT, perfume, confectionaries, toys, electronic consumables run the market.

One would say 1950 – 1970 world grew reasonably fairly. Then came the “economic boom’ – for have to have more.

South Korea was a great example of what a war ravaged nation can become. Of course they attributed that to their spiritual renewal.

I lay the greatest failure at the feet of the Middle Class Professionals, who looked like the beacons of light, who got the best from their colonial masters – geared up with civil service, Uni education, professional education etc. and generally speaking with booming economic avenues to hold their own in the post colonial world.

1985 – 2020 Orwell’s Farm in Formation

  1. Nations states begin to fail politically & in economic management
  2. Big brothers need to keep profit rolling, companies profitable, stakeholders happy in their Capitalist utopia.
  3. For this to happen Big Bro Oligarchs (BBO) need to commandeer all the economic resources of the world in all nations
  4. To this end global lending agencies worked.
  5. Corrupt national politicians played into the hands of these lending agencies, attempting huge infrastructure projects – in order to line their pockets.
  6. Other Global Organizations cashed in on national conflicts – using economic sanctions to make sovereign nations to cow tow to “Party” line of BBO.
  7. By 1990 liberal socialist policies became the manthra of the BBO to take over economics & politics. It would be Capitalism with social justice lingua – iron fist in silken gloves.
  8. For this to succeed many rights issues had to be created – to keep every fraction of society fighting another. BLM, LGBTq, racial conflict, generational conflict
  9. Digital screen provided an easily manipulated zombie generation
  10. Health issues will give them better global control than tariff control. Tariff control was too tedious a method for world domination thru economics. Health was the obvious playfield for dinosaurs to make Jurassic park again of the whole globe. Health issues will provide “innocent” methodology for which people cry for “to be saved from the virus” – so  a pingdemic, digital certificate for all global citizenry to be monitored
  11. For the project snooze noose -line to be successful, all world media have to ride party line – The Narrative of variants, jabs….Censors & journalistic guillotine functions. SS will be armed with Jabs. GESTAPO will e health I nspectors.
  12. For this vital medical conceptual nerve centres had to be recruited. UK & chosen US universities needed to fall into rank. Most plandemized behavior is seen in SAGE & UK Govt.
  13. A Strong USA was a deterrent to global expansionism – USA had to be decimated & another centre of economic significance had to be created – China came in handy
  14. China was made to provide economic leadership for plandemic. BBO believe China will be tamed by economic profit as it seems now & be a willing tamed bear performing the will of the BBO circus. Latter will be rudely awakened pretty soon.
  15. Administering the plandemic online provides a global population at the need of electronic control – kids at online school & all else.

ONLINE TEACHING & FAMILY PEACE

Online Teaching & Family Peace

When you do online studies, dopamine works more in the learning tracts of the prefrontal cortex. PFC. Dopamine spikes & if prolonged DA1 physiological receptor  is taken over by the DA 2 addictive or stress receptor. Which is the effect of cocaine. Hence some researches call the effect digital heroin & others electronic cocaine (latter is more accurate). Simultaneously, unidirectional firing mode of neurons may turn to multidirectional firing mode of stress mode. This is accompanied by increased background “noise”.

What should the teacher do?

  1. Teach interactively – though online
  2. Insist kids write down – give time for this
  3. Since time is short, you tend to rush subject material, more than in onsite teaching
  4. These has to be at least 15 min between classes, to allow serotonin to check back & dopamine to come down
  5. Minimize classes after 6 pm

What should student do?

  1. Always keep text book open – try as cuh as possible to read when in session
  2. Go thru the section before online class
  3. Write down notes
  4. If you are on screen for junk more than for studies, you will not remember or assimilate what you studied.
  5. More than 10 min of junk screen during an hour will remove studies from your RAM of brain, before it can be stored in permanent memory.
  6. Most of brain storage happens in the night under melatonin action; do not disturb that with fast screen activity after 7 pm
  7. Get ready for class with charger etc. ahead of time
  8. Do not have LED lights to illuminate

What should parents do?

  1. At  7 am, Set up the day’s 12 hrs by writing down time table for every hour with your kid.
  2. Try to supervise screen activity. Grandparents are useful
  3. Reduce LED lights in the area
  4. You could have online supervision of your kid’s screen, having discussed this with them as needed for their welfare.
  5. Be disciplined about your online habits

Nations Siege & Audit

How anarchy is taking over the world – One half door opposing the other. Also

  1. Parenthood & progeny in family
  2. Male & female sexuality
  3. Husband & wife
  4. Disciple & discipled
  5. Teacher & student
  6. Old way & new way – to function together rather than excluding each other
  7. History & present – forgiveness for history & appreciation for pioneers – Woke & cancel culture attempt anarchic rule.
  8. Apostle & pastor function together without excluding the other
  9. Institutional church & new church function together as two halves of one door.
  10.  Xgen & Xillenials, Xillenials & igen (Y), Y gen & Zgenzies function as two halves of generational succession – younger specting the older, older affirming the younger.
  11. Govt & opposition to function together
  12.  Form & freedom to function together
  13.  Respect the boundary & allow the expansion
  14.  Fake Science authority working for global dinosaurs to enslave nations, populace & economies
  15. Hopefully old capitalists & older socialists who knew the value of the nation, will function together in the face of the new liberal left & neo-capitalist onslaught to take over nations under a new Pharaonic dynasty.
  16.  Races were meant to work in harmony – critical race theory & Woke theories destroy nations as much as how capitalism did in 20th century.
  17.  Neoliberal socialism feeds neo-capitalism & enslaves sovereign nations

Audit Report

At Audit time this is what we hear.

Mat 25:32  “All the nations will be gathered before Him; and He will separate them from one another, as the shepherd separates the sheep from the goats; Mat 25:33  and He will put the sheep on His right, and the goats on the left.

The sheep-kind did the bidding of the Designing Shepherd, to be shepherds of their homes, families, work places, work fields, cities & nations. They understood that they are to be benefactors out of their competence, skill & training, serving the beneficiaries who need their expertise.  Goat-kind entered the survival of the fittest, struggle for existence, for no holes barred consumption & competition. 

We would have thought, at the height of the world’s enterprise, we would receive a report of amazing success –

  1. Prosperous,
  2. fulfilled,
  3. Well housed, 
  4. Dignified,
  5. Pink of Health,
  6. Freedom medal.

Instead we hear..

Matthew 25:35-36 

  1. ‘For I was hungry, and you gave Me something to eat;
  2. I was thirsty, and you gave Me something to drink;
  3. I was a stranger, and you invited Me in; 
  4. (36) I was naked, and you clothed Me;
  5. I was sick, and you visited Me;
  6. I was in prison, and you came to Me.’

Thankfully sheep-kind are credited for alleviating suffering caused by the goat-kind – perpetrators of hunger, thirst, alienation & disenfranchisement, nakedness, sickness & imprisonment & incarceration.

Why Hunger – 1% control 99% of world’s GDP through 20 brands. Twice as much money goes through the black.

Thirst – we have polluted water sources. Exotic vaccines but no safe drinking water. One item for fashion involves 15 litres of water. One hectare of landfill for every minute dumping the unwanted & overproduced.

Strangers – 1. Kids estranged because of too much screen time & strange spook. Living in the house as aliens with minimal social interaction 2.   Wars created to dislodge citizens who become refugees. Blurring nation boundaries. 3. Youth in search of greener pastures out of home & out of their nation. Selfie existence disconnected with family. 4 Human traficking

Naked – 1. Pornography 2 premarital sex 3 living together 4 multiple sexual partners (cervical cancer, prostatic cancer) 5 divorce remarry 6 Extramarital affairs 7  early promiscuity 8 LGBTQi 9 every form of debased sex 10 sex slaves 11 human trafficking 12 paedophilia

Caveats for Beauty & Generational Value Battles

Establish Your Values

Choose Your Values

Value Sets

VALUE SET 1VALUE SET 2
Absolute truthRelative truth
IntegrityImage
IndependenceIndividualism
Social involvementSocial isolation
ServiceSelf survival
Energetic participationPassive observation
Originality/CreativityImitation
Constant reorientationThoughtless business
Skill and careHaste and ease
Self-controlImpulsiveness
Long range perspectiveInstant gratification
ProductivityUnproductivity
Occupation as vocation/callingOccupation for survival
Profit as means to further securityProfit as the ultimate goal
HonestyDishonesty
Family ties importantNo family responsibility

INTRODUCTION – TO ALL WHO WANT TO ARISE LIKE DAVID AND BE A QUEEN LIKE ESTHER

Don’t Copy Cat – You are Original

  • Wait improves Taste
  • Haste makes Waste
  • Busting Up is Dumb
  • Be the Hero – rather than a fan
  • Ape none – You’ve got better Image
  • Save your body for the better morrow
  • Abuse follows a law of diminishing dividends
  • Thrills follow a law of higher threshold and higher risk
  • Generate the Glory within – Don’t Be Bill Boards and reflectors for other’s glory.

Wait for Your Time

  • Taste is best when time is Right.  Taste before time is bitter.  Wait for your time for maximum enjoyment of what God has for you in every season – Expect Much.  Any fruit in its time is delicious.  Where sin abounded grace abounds more

(Consume Now – turn stone to bread, more than you need, hastily, before your time, stolen bread – Stolen is Sweetest)  

  • Youth is Beautiful – We celebrate the youthful beauty given by God – Prepare to be God’s Temple.  Beauty of character – attracted to beauty that fades not.
  • Heroic – You are the hero.  God has a wonder.   How great thou art.  Dan 12:3.  You look brightest with God.

(pleasant to Eyes, attraction, visibility, glamour, fame)

  • God’s Wisdom Soars High. God’s Wisdom is the Victory.  Wisdom to Honour and exalt God.  Wisdom exalts God.  When God is the subject Glory comes.  Prov 1:7, Jam3:15,16, Prov 8:13

SMART Goals

  • Serve – Faithfully Serve the Lord in the Church
  • Mission – Bright Effective Bold witnesses in their Oikos
  • Accomplished – Skilled workmen in their chosen field
  • Romance – In due time Marriage in the Will of God
  • Testimony – Be Good role models for the younger

Beauty is God’s Gift

  • Beauty is a gift of God – honour God with your beauty
  • Make your beauty attract people to God – don’t use your beauty in a way that dishonours God.
  • Make friends with people who don’t look beautiful
  • Never abuse your beauty or entice with your beauty
  • Inward Beauty must be cultivated in order to balance external beauty 1 Pet 3:3 Prov 11:22

Ten Caveats of Beauty

  • I will Celebrate Beauty as a gift with gratitude and honour and never for dishonour
  • I will make my beauty attract people for good – not for evil.
  • I will Serve others with my beauty – make beauty part of leadership quality
  • I will make friends with people who don’t look beautiful
  • I will Never abuse my beauty or entice with my beauty
  • I will cultivate Inward Beauty in order to balance external beauty – I will not sell my beauty
  • I will Never allow others to sin by exposure – that will not be beauty as God gave
  • I will be attractive in every way – External Beauty is not my only attraction
  • I will not pride on my beauty making comparison and looking down on others

Preventing Dementia

Prevent Dementia

The updated Lancet Consortium on Dementia Prevention, published last year, concluded that 40 per cent of dementia cases could be prevented or delayed by targeting 12 modifiable risk factors, including obesity, type 2 diabetes, physical inactivity, excess alcohol intake and smoking.

Giving up smoking is particularly key, says Joanna Wardlaw, UK Dementia Research Institute group leader and a professor of applied neuroimaging at the Centre for Clinical Brain Science at Edinburgh University.

‘A natural part of the ageing process is that your brain tends to shrink a bit,’ she says, ‘and the more it shrinks, the more you are likely to have problems with cognitive ability.

‘Smoking causes accelerated thinning of parts of the brain, including the grey matter [which processes information]. If someone smokes from the age of 20 and gives up at 30, on average, someone who has never smoked won’t get the same level of damage to the grey matter until they’re 53.’

We all need to realise that the processes that cause dementia don’t just happen in old age, adds Professor Paul Matthews, a director of the UK Dementia Research Institute and head of the Department of Brain Sciences in the Faculty of Medicine at Imperial College London.

‘The FINGER study, which monitored 1,200 people in Finland at risk of cognitive decline [as a result of lifestyle factors such as lack of exercise and high blood pressure] found that interventions to help with diet, exercise and cognitive training significantly improved or maintained cognitive function,’ he says.

‘This was an important finding — the first reasonably large study in dementia to show that you could possibly reverse the progression of early phase cognitive performance loss, with interventions.’

A follow-up trial, METFINGER, is now being run in the UK and other international centres looking at providing lifestyle changes and adding in the diabetes drug metformin, which helps to lower blood sugar in the body.

‘The hypothesis is that metformin can tweak the ageing process of cells, including brain cells,’ says Professor Matthews. ‘It could have a similar effect to the impact statins have had on preventing cardiovascular disease.’

In addition to the usual lifestyle factors that we’re all advised to address, what other steps do the top dementia experts themselves take to ward off the disease? 

In bed by 10pm for a good night’s sleep 

Dr Ian Harrison, a senior research fellow at the Centre for Advanced Biomedical Imaging at University College London, who specialises in brain imaging, says: ‘When it comes to lowering my own dementia risk, I swear by a good night’s sleep. I used to go to bed later, but for the past three years I’ve been strict about going to bed at 10pm every day, even at weekends.

Dr Ian Harrison, a senior research fellow at the Centre for Advanced Biomedical Imaging at University College London, who specialises in brain imaging, says: ‘When it comes to lowering my own dementia risk, I swear by a good night’s sleep

‘The time I wake up depends on my children, aged one and three, but I set my bedtime early to give my brain the best chance to rest and have a clearout during the night.

‘The brain has a cleaning system, called the glymphatic system, which removes a build-up proteins and waste products.

‘We know from studies that the glymphatic system is 70 per cent more active when we sleep. If there is an impairment in the system due to lack of sleep, then this may lead to a build-up of proteins, including amyloid.

‘Anecdotally, we all know that we have a fuzzy head if we have a bad night’s sleep: this may be due to the glymphatic system not clearing out all the waste products.’

A review of studies by the University of Florida, published in the journal Sleep in 2017, followed up patients with sleep disorders, including obstructive sleep apnoea [where people stop breathing momentarily as they sleep], over nine and a half years and found a higher risk of them developing Alzheimer’s compared with those who had no sleep disturbances.

He says: ‘We know from studies that the glymphatic system is 70 per cent more active when we sleep’

Dr Harrison also makes sure he gets plenty of exercise.

‘We know from animal studies that exercise boosts the function of the glymphatic system,’ he says, ‘so I also go for a run and go to the gym every week, as well as cycling to work.’

Separately, but for the same reasons, Roger Watson, a professor of nursing at the University of Hull who works in care of older people, always switches off his phone at night. 

‘The light and potential buzzing can be disruptive to sleep — and studies suggest that broken sleep has an impact on our risk of dementia,’ he says. 

Chews on mints with xylitol 

Chris Fox, a professor of clinical psychiatry at the University of East Anglia Medical School, and a consultant old age psychiatrist at Norfolk and Suffolk NHS Foundation Trust, says: ‘As well as looking after my health generally, I take good care of my teeth to reduce the risk of dementia.

‘I use mints containing xylitol [an artificial sweetener] to keep the microbiome, the community of bacteria in the mouth, healthy.

‘This not only reduces dental cavities but xylitol actually gets rid of nasty bacteria, too. There is emerging evidence that it creates a healthier oral microbiome.

Chris Fox, a professor of clinical psychiatry at the University of East Anglia Medical School, and a consultant old age psychiatrist at Norfolk and Suffolk NHS Foundation Trust, says: ‘As well as looking after my health generally, I take good care of my teeth to reduce the risk of dementia’

‘One study from Bristol found the same bugs that can cause problems in the mouth were found in post-mortem brains of people who died from Alzheimer’s.’

(Note, xylitol in excess may cause bloating or diarrhoea in those with a sensitive gut.) One suggestion is that oral health may be linked to dementia as the bacteria may trigger inflammation in the brain.

The thinking is that porphyromonas gingivalis, the bacterium in the mouth that causes gum disease, crosses the blood brain barrier — a protective boundary between the bloodstream and the brain.

This can potentially alter brain cells, contributing to dementia, explains Karl Herholz, a professor in clinical neuroscience at Manchester University.

‘We know the disease begins around 20 to 30 years before symptoms become apparent, so it makes sense to have good oral health by brushing and visiting your dentist regularly, which I ensure I do to protect myself against dementia,’ he says. 

Avoids walking besides busy roads 

Dr Tom Russ, a consultant old age psychiatrist, director of the Alzheimer’s Scotland Dementia Research Centre, at the University of Edinburgh, says: ‘I make a conscious effort to avoid walking along main roads and find back street routes where possible’

Dr Tom Russ, a consultant old age psychiatrist, director of the Alzheimer’s Scotland Dementia Research Centre, at the University of Edinburgh, says: ‘I make a conscious effort to avoid walking along main roads and find back street routes where possible.’

Air pollution was added to the list of modifiable factors to reduce dementia by the Lancet Commission in 2020. This follows studies, including one in Canada of 6.6 million people, that have shown living on a main road is associated with a higher risk of dementia.

Those living within 50 metres of a major road were 7 per cent more likely to develop dementia than people living more than 300 metres away, where fine particulate matter levels [the particles of pollution that can get into the bloodstream] can be up to ten times lower.

‘Pollutant distribution depends on weather conditions, though,’ adds Dr Russ. Heatwaves and high pressure, for instance, can create stagnant air and pollutants are not dispersed — and winds can distribute pollutants over a wide area.

‘There are questions that remain unanswered about pollution and the brain, though. One is whether pollution is just a subtle effect on your thinking skills or does it have a structural effect on the brain.’

There is some suggestion that pollution contributes to brain inflammation, says Gill Livingston, a professor of mental health in older people at University College London. ‘My work is located near one of the most polluted roads in London, so if I walk there I drop back a street and walk parallel to the road, to avoid traffic.

‘It’s why it is also important to try to get away from pollution as much as possible, by spending leisure time or doing exercise in parks or in the countryside.’

She also avoids exposure to wood fires and passive smoking as both produce particulate matter. 

Alcohol

Professor Paul Matthews, a director of the UK Dementia Research Institute and head of the Department of Brain Sciences in the Faculty of Medicine at Imperial College London, says: ‘We’ve recently done a study that shows that there is an association between drinking alcohol and higher rates of brain volume loss.

‘In adults, the brain begins to lose half a teaspoon of its size [about 0.3 per cent of its volume] every year, and on average drinking two small glasses of wine a day doubles the rate of volume loss.

‘The base rate is low, though — doubling only increases the volume loss from 0.3 to 0.64 per cent. But we know people who experience more rapid rates of brain volume loss tend to develop more cognitive symptoms earlier than people who don’t have a rapid rate.

‘We have observed this association between alcohol and loss of brain volume in people who drank within the normal range (not excessively), though the effect was larger in those who drank heavily.

Eye & Ear Test

Has an eye test every year 

While it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked

+10

  •  

While it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked

It’s now well-established that hearing loss — specifically, hearing loss when you don’t wear hearing aids if you need them — is a leading preventable cause of dementia, and addressing it could reduce the risk by 8 per cent, according to the Lancet Commission on dementia prevention.

Mild hearing loss doubled dementia risk, moderate hearing loss tripled it and severe hearing loss increased the risk by five times.

The theory is that not being able to hear well and the lack of social stimulation that follows is associated with a higher risk of brain shrinkage and damage.

But while it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked.

‘The less well we hear — or lip read, which is key for our understanding of what’s being said — the less opportunity there is to have meaningful conversations that can stimulate the brain.

‘It’s why I make sure I have an eye test at least once a year. And if you think you might need glasses, you should see your optician.’ 

Doesn’t add salt when cooking 

Dr Sarah-Naomi James, a dementia research fellow at University College London, says: ‘Dementia doesn’t just happen in old age, it starts decades before’

Dr Sarah-Naomi James, a dementia research fellow at University College London, says: ‘Dementia doesn’t just happen in old age, it starts decades before. We now know that there is an association between high blood pressure [around 140/90 from midlife, roughly between the age of 40 and 50] and developing dementia.

‘I’m in my early 30s but I look after my physical health and I’m particularly careful about checking salt levels on packets. And I don’t add salt to food, either.

‘Blood pressure tends to rise with age, but there is something about what happens in mid-life that seems to be particularly important, although we don’t know what the mechanism is yet. One theory, though, is the pulsating pressure damages the brain.’ 

And deliberately uses ‘wrong’ hand 

Another step Dr MacSweeney takes is to try to put pressure on her brain by using her non-dominant hand for some tasks.

‘So as well as making sure I brush my teeth and use interdental brushes [to protect against mouth bacteria linked to dementia], I swap hands when using my toothbrush,’ she says. ‘Using the non-dominant hand can provide an additional workout for the brain.’

Similarly, she ‘supercharges’ her exercise regimen.

‘It’s well-recognised that exercise plays a role in helping reduce the risk of Alzheimer’s, with a 2019 study finding that aerobic exercise may specifically help combat changes in the brain associated with dementia,’ she says.

‘But research also tells us that you’ll get an even greater boost if you do a form of exercise that say, unlike jogging, makes you have to think about what you’re doing.

‘So as well as running, I do HIIT — high-intensity interval training — four to five times a week.

Work & Write in Two Languages

Carol Brayne (pictured) says: ”Our brains change quite a bit as we age, in the ways they are wired, and I think at the highest level our brains are meant to be stimulated’

Carol Brayne, a professor of public health at the University of Cambridge, says: ‘Studies have shown that factors such as social engagement, intellectual engagement, having a complex occupation and higher education are associated with a lower risk of dementia, although they don’t eradicate it completely.

‘Our brains change quite a bit as we age, in the ways they are wired, and I think at the highest level our brains are meant to be stimulated.

‘We know that from child development: if you don’t stimulate a child, their brain won’t develop.

‘We are organisms that respond to the environment, and we need stimulation in order to maintain things.

‘My message would be that you need to do things you enjoy, though. Enrich your life by taking up activities that you like and can become better at, at any life stage.

Science & Reason Publications by Dr Lalith Mendis

Covid Science Clips 100 – 187

  • 100 Happy Hour – WHO Weakens Nations 1 – Broken Relationship.-Dr.Lalith Mendis (03.11.2020)- https://youtu.be/KO1RxhusUa0
  • 103 Character & Curriculum – Balancing Calibration & Celebration In R Brain Kids For Exam Success.- https://youtu.be/Adj6sJElO8o
  • Covid Science 104 Two Camps -Shut Down Or Shield. HCQ Or No HCQ, Global or Nation.-Dr.Lalith Mendis- https://youtu.be/96ybw0Vh8gM
  • Happy Hour 106-Five Digital Laws for Brain Bright & Heart Warm & Fruit by the river/barren by blight- https://youtu.be/j6UguOTD-MU
  • Science & Reason,Covid 107 – Debt Extractors & Debt Servicers- Globalist & Nation.-Dr.Lalith Mendis – https://youtu.be/1yUZLz5SdTE
  • 108 Study On Screen – Keep Brain Bright. Sleep Well, Manage Under 5 yrs Well.-Dr.Lalith Mendis- https://youtu.be/wlXDZWeC2Ks
  • 110 Timely Thoughts Bread & Not Stones,Egg Not Scorpion, Fish Not Serpent.Invasion -Thief,Moth,Rust.- https://youtu.be/mQ6aeQUQpMU
  • 112 Covid – Pathology, Pharmacology, Early Treatment, Early Home Therapy, Swiss Epidemiology .- https://youtu.be/iMc7PLjWxY4
  • Covid 113 – PCR Testing When & How. When False Positive.-Dr.Lalith Mendis (18.11.2020)- https://youtu.be/Yq13Ww8rji8
  • 114 Dad Hero kallesthenics GARTS Grip & Rope Thrills To Make Kid Brain Brilliant.-Dr.Lalith Mendis- https://youtu.be/uEUzbMMKnKc
  • 115 – Vaccines – Scientific Consideration For Laymen & Professionals.-Dr.Lalith Mendis (20.11.220)- https://youtu.be/iJAI26Ye_Ls
  • 118 PREVENTING DIGITAL BURNOUTCyber bullying,Curriculum,Career, Character Choices.DR.Lalith Mendis- https://youtu.be/pY4ObqEdlJc
  • 120 Which Vaccine – Why Vaccine Furore – Every Child A Star.-Dr.Lalith Mendis (28.11.2020) – https://youtu.be/c4ckm_pzxzI
  • 122 Covid Science – Run Up to the Rush Up – Spike Protein.-DR.Lalith Mendis (05.12.2020) – https://youtu.be/-qC156qL3C8
  • 124 Historicity & sociology of Christmas.-Dr.Lalith Mendis (13.12.2020) – https://youtu.be/pQ0sntDiPTU
  • 125 Alcohol – Friend In Need Or Fiend. 12 Steps Down & 6 Up -Dr.Lalith Mendis (17.12.2020) – https://youtu.be/2ycojzlHODA
  • 126 Minding 7 tracts for 12 Health Systems – 7 H Hurt to hoard.-DR.Lalith Mendis (20.12.2020) – https://youtu.be/kjH75FduTG8
  • 128 Twelve Social Genes that Made Thrillennials – Contest Generation.-DR.Lalith Mendis (23.12.2020) – https://youtu.be/GLiXsy3h-Bc
  • 130 Gift Or Prize – Fear To Favour. Self Critic – Defence Of A Depreciated Child.-DR.Lalith Mendis – https://youtu.be/ndkV6vgIvMo
  • 131 7 Surfing Tips For Kids For Covid Times Improving 3AAA Rating.-DR.Lalith Mendis (27.12.2020) – https://youtu.be/po3fHDqN7J0
  • 133 Covid Update & QR Code for buy & sell. Covid immune reactions.-DR.Lalith Mendis (31.12.2020) – https://youtu.be/Hr2JdN9KiSE
  • 136 Triangle Of Power Victim Aggressor Elect-returning Nations To The Populace-CEO. .-DR.Lalith J Mendis –https://youtu.be/2epja8hN6sM
  • 137 Covid Virus Update – Bears Growl & Doves Moan When Pharaohs Rule.DR. Lalith J Mendis(18.01.2021) – https://youtu.be/2MozJ9v5GBk
  • 139 Ancient Ceylon Gold Rush WE Tennant Tarshish, Great Emporium Manthai.-DR.Lalith J Mendis – https://youtu.be/1K0f_rhBcGw
  • 141 – GREAT REGRESS then we knew but now we slip – Looking for Fathers when malafiscence rules – horns butt, hoofs trample.- DR.Lalith J Mendis – https://youtu.be/GIRCHQxIXUw
  • 142 Happy Gastronomics Saving GBU Good Bad Ugly Mixed Up Generation. Entertain Nixes Educate. – https://youtu.be/fonfs_uiJQQ
  • 144Kids Home School Parents-Top Down Regulation අපේක්ෂා අරම්භය තරණය නිමාව Reward.DR.Lalith J Mendis – https://youtu.be/UUjtj7TewnE
  • Counsellers On Digital Toxicity & Addiction – Way Forward; Empathic Motor Therapy.-Dr.lalith Mendis – https://youtu.be/duZB5RjMvN0
  • 146 Training Customer is King Generation.පරිභෝජිකයා රජු පරපුර ශික්ෂණය.Dr.Lalith J Mendis(06.02.2021) – https://youtu.be/oV_fYBXZaXk
  • 147 Digital addiction is gateway to other addictions – train for initiation navigation reward early – Top down regulation.-DR.Lalith J Mendis – https://youtu.be/s8OjuGJhEnI
  •  148 Triology-Afraid,Naked,Hiding & 5 features of social pathogenesis -පරම්පරා විසන්දිය , ප්‍රතිකර්මය – https://youtu.be/vUTMum6qtmc
  • 149 Valentine day special – alcohol, sexual impulsivity -Wait makes taste great. Haste makes waste – https://youtu.be/a_bd1L7box8
  • 150 Passing The Baton-7 Traits You Premiere & Pass On To Team-Run Life Alongside.DR.Lalith J Mendis – https://youtu.be/LztqcK-4Nxg
  • 152 VIBGYOR for parents & kid training your tongue.Red says Remedy.Orange prepare.Dr.Lalith Mendis – https://youtu.be/-YCyvfdEbKE
  • 153 Einstein’s WW IV – war against HMS HUMANITY – are we there.-DR.Lalith J Mendis (28.02.2021) – https://youtu.be/decVAL6kxgU
  • 155 Harvest of Life – who is lord – seaon, seed bag, time of activation, relationships, placement, space of influence, opportunity, FINAL ACCOUNT.- DR.Lalith J Mendis (06.03.2021) – https://youtu.be/O-dqm3bZizo
  • 158 Sri Lanka Forgive Me & Save Us From The Stone Age Weapons.-Dr.Lalith Mendis (13.03.2021) – https://youtu.be/FpM8UxHy6B0
  • 160 Covid Clots – Flattery Intoxicates, Xillennials, Train Brain & Brawn Together – 13 To 33 yrs . – https://youtu.be/BXnqsiMHt3o
  • 162 Half Time when your tree of life transitions to an Orchard. Success to Legacy.-Dr.Laith J Mendis – https://youtu.be/fCEG-7wvT5U
  • 165 Most Famour Kangaroo Court & Cardiac Tamponade – Injustice Is Finished.-DR.Lalith J Mendis – https://youtu.be/THtaDaspzdQ
  • 166 Dawn on Dark Night of my Soul, weapons of victimization, Bandaged Humanity.-Dr.Lalith J Mendis – https://youtu.be/mdw1NADfZx8
  • 169 Resurrection Hoax Or History Prof Anderson. Prof Oriental Law, Uni London Examines The Case. – https://youtu.be/2aQ3zUiJZQM
  • 170 Eng Tamil Sexuality Masculinity Femininity at 23,33,43 yrs half time வயதில் பாலியல்,ஆண்மை,பெண்மை – https://youtu.be/DCD_LWZsQlI
  • 168 Eng Tam Crucifixion Earthquake Eclipse Kangaroo Court 1- சிலுவை அறைதல், பூமி அதிர்ச்சி, கிரகணம், கங்காரு நீதிமன்றம் 1.- DR.Lalith J MEndis (07.04.2021) – https://youtu.be/pHlo25VTn44
  • 171 Life Wheel Romance & Stations Base 13, 23, 33, 43 Masculinity, femininity- අට චර්යා දිවි පත ප්‍රේමන්විතය සෞදර්‍ය සමපාත ලිංගිකත්වය https://youtu.be/TDdK6nGy_eI
  • 172 Parents & Kids Train Champions – Mistake Manage To Fetch Them Forward – Catch Their GABA Time. – https://youtu.be/UdWjlI2N064
  • ‘173 අවකාශ 8 – ජීවන චක්‍රය 8. ශ්‍රම ජීවිත තුලනය- வாஇடைவெளிகள்ழ்க்கை சக்கரம்- 8 – தொழில்சார்வாழ்கை. – https://youtu.be/ZWj4qYzCBqA
  • 174 Making Champions At 13, 23, 33, 43 yrs දෙමපියන් දූදරුවන් සූරයන් පුහුණු කිරීම අවු. 13,23,33,43 . – https://youtu.be/p1mk5l1Ip20
  • 175 Eight Stations In Life – Romance Rules & Table Of Life, People & Provision.-DR.Lalith J Mendis – https://youtu.be/gd_VYXhu_gA
  • 177 Age Gracefully Manifesto – Take Care Those Whom You Lead Will One Day Lead You – Home Or Work. – https://youtu.be/l60exvqZXaE
  • 179 Covid Clot Update, Oxygen & Vitriol In The Mouth.-Dr.Lalith J Mendis (02.05.2021) – https://youtu.be/g_YkASpm3oM
  • 181 Prevention of Digital Burn Out – ඩිජිටල් ආධානය හා ධාහය වලකමු.-DR.Lalith J Mendis (07.05.2021) – https://youtu.be/hajucxelp7o
  • 182 Celebrate Mom – Recipe For Home. Motherhood – Last Bastion Of Civilization.-DR.Lalith J Mendis- https://youtu.be/5rghDTzq9Yc
  • Mom The Last Bastion Of Civilization By Dr Lalith Mendis. Narration – Malaika Peiris – https://youtu.be/9A6i3rmfp0Y
  • 184 – Four Generational Wisdom For Refiring In Mature Years.-DR.Lalith J Mendis (11.05.2021) –https://youtu.be/QkCt_dG_hQ4
  • 186 Every Hour Counts For Sleep-When Gym Is Closed Or You’re Scared. Generational Connect 70 yrs 50 – https://youtu.be/aVHqb1mfZ54


  • 101 දේශයේ අවමාන 1 – බිදුනු සබඳතා.-Dr.Lalith Mendis (03.11.2020)- https://youtu.be/mZdCJWbdXkI
  • 102 ප්‍රභාශිත  ප්‍රාසාංගික දරු දෙවග පැවරුම හා සැමරුම Coaching Parents.-DR.Lalith Mendis (05.11.2020)- https://youtu.be/7PhKSz9dvcU
  • 105 විද්වත් විමංසා -ගෝලීය දේශීය බල ගැටුම්,වෛරස , Vaccine.-DR.Lalith Mendis (08.11.2020) – https://youtu.be/fdT6jnYy74Q
  • විද්වත් 109- පරම්පරා 3 අනුප්‍රාප්තිය – ලොව දිනන්නෝ,පුරුක් පරපුර,ලොව සොලවන්නෝ.-Dr.Lalith Mendis-https://youtu.be/ZIFGGISoa1Y
  • 111 සංකල්පනා වත්මන් කෝවිඩ් හා ගල් නොව රොටී,ගෝණුස්සකු නොව බිත්තර,සර්පයා නොව මළුව-උමං,කාවෝ,මලකඩ වලකමු.- https://youtu.be/xPM-EazoUBA
  • 116 Family Health- අභියෝගය,කෝවිඩ්,ක්‍රීඩා ගම්‍යතා Coach -තාත්තා වීරයා.-DR.Lalith Mendis (21.11.2020) – https://youtu.be/tg87Vfmv-h0
  • 117 Do These 10 Ladders & Snakes Will Not Get Your Kids-තත්තා ළමුන් දිනවන Super Game 10.- https://youtu.be/dQChvbm59vE
  • 119 – දෙමව්පියන් දිනූ කුසලානය-දූ දරුවෝ.-Dr.Lalith Mendis (27.11.2020) – https://youtu.be/Z9Eelkf0bcc
  • 121 Vaccine ක්‍රමවේද- විද්‍යාව ,ආර්ථිකය , රාජ්‍යතන්ත්‍රය.-Dr.Lalith Mendis (29.11.2020) –  https://youtu.be/Gw9659Xb1-g
  • 123 එන්නත් පවුල් සුරකුම ගෝලීය ප්‍රවනතා – වැටත් නියරත් ගොයම කෑ නම්.-DR.Lalith Mendis (09.12.2020)- https://youtu.be/WH_C9K_BlKw
  • 127 පථ 7 හා  ශික්ෂා  7 – සෞඛ්‍ය පදනම 12.-DR.Lalith Mendis (20.12.2020)- https://youtu.be/SI_Mi9lx2ZU
  • 129 – Bottom Up ලොවක් බිහි කළ සමාජ ජෙනෝමය සහ වත්මන් පරපුර 1990- 2020 අධිගාමී ප්‍රතිවාදී ත්‍රාසශීලී. – https://youtu.be/qKS4nbGQkb4
  • 132 යතුරු 7 – 3AAA රටේ පවුල රකින මනෝ විද්‍යා ප්‍රඥා.-DR.Lalith Mendis (27.12.2020) – https://youtu.be/3DbQjZlahpI
  • 134 වන Covid කොවිඩ් යාවත්කාලීන කිරීම – අලුත් පුවත්, QR code, ගෝලීය පෙරලිය විද්‍යාව හා අවිද්‍යාව – https://youtu.be/DTGLK-CTjg8
  •   135 බෙලහීන බලවන්ත අසාදාරන යමක් ත්‍රිකෝනය QUO VADIS-වරද කාගේද , කඩවුනු පොරොන්දුව.-DR.Lalith J Mendis – https://youtu.be/UovOYn3IeR0
  • 138 කෝවිඩ් Update අළුත් වෛරස් ප්‍රබේද ප්‍රතිශක්ති ඌනතා- වැට නියර ගොයම් කන විට.-DR.Lalith J Mendis – https://youtu.be/5p1NUZlrq9c
  • 140-Covid Spike Protein වෙනුවට අළුත් ඖෂධ ආවේ පුරාණ රත්රන් වෙරළ Ancient Ceylon වලසුන් හා පරවියන්. https://youtu.be/UoV882veWbk
  • 143 කුරිරු ගොර සපුන් වූ අවිද්‍යා – අධ්‍යාපන පරදවන අවිචාරය හා ළමුන්.-Dr.Lalith J Mendis (28.01.2021) – https://youtu.be/Ea9-ahofMc4
  • 143-7 Tracts Prophecy,Serve Teach Barnabas Invest Lead Mercyමනෝරූප සේවා ගුරු පුහුණු ආයෝජක නායක කරුන – https://youtu.be/LjczpeEX5vc
  • මනෝරූප සේවා ගුරු පුහුණු ආයෝජක නායක කරුන.-Dr.Lalith J Mendis – https://youtu.be/97o8ruvipyI
  • 151 පරම්පරා ප්‍රගමනය- වත්මන් වතගොත කපුටු කාක් චරිතාංග 7 ප්‍රශ්න 7 .-DR.Lalith J Mendis (20.02.2021) – https://youtu.be/OVk8kjEYJnE
  • 154 අයින්ස්ටයින්ගේ 4 වන ලෝක මහා සංග්‍රාමය එළු බැටලු යුද්ධය ගෝලීය අක්‍රමන.-DR.Lalith J Mendis – https://youtu.be/0JeILfPxk8I
  • 156 ජීවන අස්වැන්නේ- වවමුද ? කමුද ? උල හෝ පිල .කටු වගා ඵල යට කරයිද ?.-DR.Lalith J Mendis (06.03.2021) – https://youtu.be/YJowstjEPW4
  • ජීවන අස්වැන්න | Episode 156 – https://youtu.be/e1jl3B3DAd0
  • 159 ශ්‍රී ලංකා සමා වෙන්න පාෂාණ යුගයේ ගල් ආයුධ වලින් ගලවා ගන්නේ.-Dr.Lalith Mendis (13.03.2021) – https://youtu.be/tVgHM2uCxNw
  • 161 ලොව වනසන දූෂ්‍ය ප‍්‍රඥා 12 අභිබවා චාරික මාලිමාවක් ඇත Moral Magnetism vs Corrupt Wisdom. – https://youtu.be/6A0oqeFiIZw
  • 163 ජීවිත අස්වැන්නේ අවුරුදු 33 – 43. 43න් එහා නොනිමි පහන.-Dr.Laith J Mendis (28.03.2021) – https://youtu.be/7wokhP0Fth8
  • 164 අසාධාරණය රජ කල සිකුරාදා නඩු විභාගය – පොලව පැලුනු වගයි- Kangaroo Court-Cardiac Tamponade. – https://youtu.be/90Ia6VkxVj4
  •  167 යුගාංතික සංග්‍රාමය නිරායුද සම්මුතිය.-DR.Lalith J Mendis (04.04.2021) – https://youtu.be/V8O5TNTz0h4
  • 176 ජීවිත සිතුවම Life Map & Table – ජීවන මේසය අට කාරක – අටකාරක සමෘද්ධිය.-DR.Lalith J Mendis – https://youtu.be/te2CRgpQnlA
  • 178 වියපත් ස්වර්ණමය සැන්දෑවේ- දිවි ලිද ලග බොලොක්කය බිදෙන දින.-DR.Lalith J Mendis (19.074.2021) – https://youtu.be/RiEu-ZQEsho
  • 180 කෝවිඩ් ඔක්සිජන් මගේ මුව හුස්ම හිර නොකරයි.-Dr.Lalith J Mendis (02.05.2021) – https://youtu.be/wfasGOrSBvQ
  • 183 මාතෘත්වය සමරමු – තොටිල්ල නලවන අත .-DR.Lalith J Mendis (07.05.2021) – https://youtu.be/Z0gea3ecG7A
  • 187 අපේක්ෂා පූර්ණ පායෙන පැය DMN නෙට්වර්ක් ගෙදරම ජිම් අභ්‍යාස .කොවිඩ් පරදන චරිතාංග 7. – https://youtu.be/xbKYdDQtKko
  •  

Analysis by 57 Scientists of Pharmacology & Immunology

Analysis by 57 Scientists of Pharmacology & Immunology

Roxana Bruno1, Peter McCullough2, Teresa Forcades i Vila3, Alexandra Henrion-Caude4, Teresa García-Gasca5, Galina P. Zaitzeva6, Sally Priester7, María J. Martínez Albarracín8, Alejandro Sousa-Escandon9, Fernando López Mirones10, Bartomeu Payeras Cifre11, Almudena Zaragoza Velilla10, Leopoldo M. Borini1, Mario Mas1, Ramiro Salazar1, Edgardo Schinder1, Eduardo A Yahbes1, Marcela Witt1, Mariana Salmeron1, Patricia Fernández1, Miriam M. Marchesini1, Alberto J. Kajihara1, Marisol V. de la Riva1, Patricia J. Chimeno1, Paola A. Grellet1, Matelda Lisdero1, Pamela Mas1, Abelardo J. Gatica Baudo12, Elisabeth Retamoza12, Oscar Botta13, Chinda C. Brandolino13, Javier Sciuto14, Mario Cabrera Avivar14, Mauricio Castillo15, Patricio Villarroel15, Emilia P. Poblete Rojas15, Bárbara Aguayo15, Dan I. Macías Flores15, Jose V. Rossell16, Julio C. Sarmiento17, Victor Andrade-Sotomayor17, Wilfredo R. Stokes Baltazar18, Virna Cedeño Escobar19, Ulises Arrúa20, Atilio Farina del Río21, Tatiana Campos Esquivel22, Patricia Callisperis23, María Eugenia Barrientos24, Karina Acevedo-Whitehouse5,*

SARS-CoV-2 mass vaccination: Urgent questions on vaccine safety that demand answers from international health agencies, regulatory authorities, governments and vaccine developers

1Epidemiólogos Argentinos Metadisciplinarios. República Argentina.
2Baylor University Medical Center. Dallas, Texas, USA.
3Monestir de Sant Benet de Montserrat, Montserrat, Spain
4INSERM U781 Hôpital Necker-Enfants Malades, Université Paris Descartes-Sorbonne Cité, Institut Imagine, Paris, France.
5School of Natural Sciences. Autonomous University of Querétaro, Querétaro, Mexico.
6Retired Professor of Medical Immunology. Universidad de Guadalajara, Jalisco, Mexico.
7Médicos por la Verdad Puerto Rico. Ashford Medical Center. San Juan, Puerto Rico.
8Retired Professor of Clinical Diagnostic Processes. University of Murcia, Murcia, Spain
9Urologist Hospital Comarcal de Monforte, University of Santiago de Compostela, Spain.
10Biólogos por la Verdad, Spain.
11Retired Biologist. University of Barcelona. Specialized in Microbiology. Barcelona, Spain.
12Center for Integrative Medicine MICAEL (Medicina Integrativa Centro Antroposófico Educando en Libertad). Mendoza, República Argentina.

Abstract

Since the start of the COVID-19 outbreak, the race for testing new platforms designed to confer immunity against SARS-CoV-2, has been rampant and unprecedented, leading to emergency authorization of various vaccines. Despite progress on early multidrug therapy for COVID-19 patients, the current mandate is to immunize the world population as quickly as possible. The lack of thorough testing in animals prior to clinical trials, and authorization based on safety data generated during trials that lasted less than 3.5 months, raise questions regarding the safety of these vaccines. The recently identified role of SARS-CoV-2 glycoprotein Spike for inducing endothelial damage characteristic of COVID-19, even in absence of infection, is extremely relevant given that most of the authorized vaccines induce the production of Spike glycoprotein in the recipients. Given the high rate of occurrence of adverse effects, and the wide range of types of adverse effects that have been reported to date, as well as the potential for vaccine-driven disease enhancement, Th2-immunopathology, autoimmunity, and immune evasion, there is a need for a better understanding of the benefits and risks of mass vaccination, particularly in the groups that were excluded in the clinical trials. Despite calls for caution, the risks of SARS-CoV-2 vaccination have been minimized or ignored by health organizations and government authorities. We appeal to the need for a pluralistic dialogue in the context of health policies, emphasizing critical questions that require urgent answers if we wish to avoid a global erosion of public confidence in science and public health.

Introduction

Since COVID-19 was declared a pandemic in March 2020, over 150 million cases and 3 million deaths have been reported worldwide. Despite progress on early ambulatory, multidrug-therapy for high-risk patients, resulting in 85% reductions in COVID-19 hospitalization and death [1], the current paradigm for control is mass-vaccination. While we recognize the effort involved in development, production and emergency authorization of SARS-CoV-2 vaccines, we are concerned that risks have been minimized or ignored by health organizations and government authorities, despite calls for caution [2-8].

Vaccines for other coronaviruses have never been approved for humans, and data generated in the development of coronavirus vaccines designed to elicit neutralizing antibodies show that they may worsen COVID-19 disease via antibody-dependent enhancement (ADE) and Th2 immunopathology, regardless of the vaccine platform and delivery method [9-11]. Vaccine-driven disease enhancement in animals vaccinated against SARS-CoV and MERS-CoV is known to occur following viral challenge, and has been attributed to immune complexes and Fc-mediated viral capture by macrophages, which augment T-cell activation and inflammation [11-13].

In March 2020, vaccine immunologists and coronavirus experts assessed SARS-CoV-2 vaccine risks based on SARS-CoV-vaccine trials in animal models. The expert group concluded that ADE and immunopathology were a real concern, but stated that their risk was insufficient to delay clinical trials, although continued monitoring would be necessary [14]. While there is no clear evidence of the occurrence of ADE and vaccine-related immunopathology in volunteers immunized with SARS-CoV-2 vaccines [15], safety trials to date have not specifically addressed these serious adverse effects (SAE). Given that the follow-up of volunteers did not exceed 2-3.5 months after the second dose [16-19], it is unlikely such SAE would have been observed. Despite92 errors in reporting, it cannot be ignored that even accounting for the number of vaccines administered, according to the US Vaccine Adverse Effect Reporting System (VAERS), the number of deaths per million vaccine doses administered has increased more than 10-fold. We believe there is an urgent need for open scientific dialogue on vaccine safety in the context of large-scale immunization. In this paper, we describe some of the risks of mass vaccination in the context of phase 3 trial exclusion criteria and discuss the SAE reported in national and regional adverse effect registration systems. We highlight unanswered questions and draw attention to the need for a more cautious approach to mass vaccination.

SARS-CoV-2 phase 3 trial exclusion criteria

With few exceptions, SARS-CoV-2 vaccine trials excluded the elderly [16-19], making it impossible to identify the occurrence of post-vaccination eosinophilia and enhanced inflammation in elderly people. Studies of SARS-CoV vaccines showed that immunized elderly mice were at particularly high risk of life-threatening Th2 immunopathology [9,20]. Despite this evidence and the extremely limited data on safety and efficacy of SARS-CoV-2 vaccines in the elderly, mass-vaccination campaigns have focused on this age group from the start. Most trials also excluded pregnant and lactating volunteers, as well as those with chronic and serious conditions such as tuberculosis, hepatitis C, autoimmunity, coagulopathies, cancer, and immune suppression [16-29], although these recipients are now being offered the vaccine under the premise of safety.

Another criterion for exclusion from nearly all trials was prior exposure to SARS-CoV-2. This is unfortunate as it denied the opportunity of obtaining extremely relevant information concerning post-vaccination ADE in people that already have anti-SARS-Cov-2 antibodies. To the best of our knowledge, ADE is not being monitored systematically for any age or medical condition group currently being administered the vaccine. Moreover, despite a substantial proportion of the population already having antibodies [21], tests to determine SARS-CoV-2-antibody status prior to administration of the vaccine are not conducted routinely.

Will serious adverse effects from the SARS-CoV-2 vaccines go unnoticed?

COVID-19 encompasses a wide clinical spectrum, ranging from very mild to severe pulmonary pathology and fatal multi-organ disease with inflammatory, cardiovascular, and blood coagulation dysregulation [22-24]. In this sense, cases of vaccine-related ADE or immunopathology would be clinically-indistinguishable from severe COVID-19 [25]. Furthermore, even in the absence of SARS-CoV-2 virus, Spike glycoprotein alone causes endothelial damage and hypertension in vitro and in vivo in Syrian hamsters by down-regulating angiotensin-converting enzyme 2 (ACE2) and impairing mitochondrial function [26]. Although these findings need to be confirmed in humans, the implications of this finding are staggering, as all vaccines authorized for emergency use are based on the delivery or induction of Spike glycoprotein synthesis. In the case of mRNA vaccines and adenovirus-vectorized vaccines, not a single study has examined the duration of Spike production in humans following vaccination. Under the cautionary principle, it is parsimonious to consider vaccine-induced Spike synthesis could cause clinical signs of severe COVID-19, and erroneously be counted as new cases of SARS-CoV-2 infections. If so, the true adverse effects of the current global vaccination strategy may never be recognized unless studies specifically examine this question. There is already non-causal evidence of temporary or sustained increases138 in COVID-19 deaths following vaccination in some countries (Fig. 1) and in light of Spike’s pathogenicity, these deaths must be studied in depth to determine whether they are related to vaccination.

Unanticipated adverse reactions to SARS-CoV-2 vaccines

Another critical issue to consider given the global scale of SARS-CoV-2 vaccination is autoimmunity. SARS-CoV-2 has numerous immunogenic proteins, and all but one of its immunogenic epitopes have similarities to human proteins [27]. These may act as a source of antigens, leading to autoimmunity [28]. While it is true that the same effects could be observed during natural infection with SARS-CoV-2, vaccination is intended for most of the world population, while it is estimated that only 10% of the world population has been infected by SARS-CoV-2, according to Dr. Michael Ryan, head of emergencies at the World Health Organization. We have been unable to find evidence that any of the currently authorized vaccines screened and excluded homologous immunogenic epitopes to avoid potential autoimmunity due to pathogenic priming.

Some adverse reactions, including blood-clotting disorders, have already been reported in healthy and young vaccinated people. These cases led to the suspension or cancellation of the use of adenoviral vectorized ChAdOx1-nCov-19 and Janssen vaccinesin some countries. It has now been proposed that vaccination with ChAdOx1-nCov-19 can result in immune thrombotic thrombocytopenia (VITT) mediated by platelet-activating antibodies against Platelet factor-4, which clinically mimics autoimmune heparin-induced thrombocytopenia [29]. Unfortunately, the risk was overlooked when authorizing these vaccines, although adenovirus-induced thrombocytopenia has been known for more than a decade, and has been a consistent event with adenoviral vectors [30]. The risk of VITT would presumably be higher in those already at risk of blood clots, including women who use oral contraceptives [31], making it imperative for clinicians to advise their patients accordingly.

At the population level, there could also be vaccine-related impacts. SARS-CoV-2 is a fast-evolving RNA virus that has so far produced more than 40,000 variants [32,33] some of which affect the antigenic domain of Spike glycoprotein [34,35]. Given the high mutation rates, vaccine-induced synthesis of high levels of anti-SARS-CoV-2-Spike antibodies could theoretically lead to suboptimal responses against subsequent infections by other variants in vaccinated individuals [36], a phenomenon known as “original antigenic sin” [37] or antigenic priming [38]. It is unknown to what extent mutations that affect SARS-CoV-2 antigenicity will become fixed during viral evolution [39], but vaccines could plausibly act as selective forces driving variants with higher infectivity or transmissibility. Considering the high similarity between known SARS-CoV-2 variants, this scenario is unlikely [32,34] but if future variants were to differ more in key epitopes, the global vaccination strategy might have helped shape an even more dangerous virus. This risk has recently been brought to the attention of the WHO as an open letter [40].

Discussion

The risks outlined here are a major obstacle to continuing global SARS-CoV-2 vaccination. Evidence on the safety of all SARS-CoV-2 vaccines is needed before exposing more people to the184 risk of these experiments, since releasing a candidate vaccine without time to fully understand the resulting impact on health could lead to an exacerbation of the current global crisis [41]. Risk-stratification of vaccine recipients is essential. According to the UK government, people below 60 years of age have an extremely low risk of dying from COVID-191 187 . However, according to Eudravigillance, most of the serious adverse effects following SARS-CoV-2 vaccination occur in people aged 18-64. Of particular concern is the planned vaccination schedule for children aged 6 years and older in the United States and the UK. Dr. Anthony Fauci recently anticipated that teenagers across the country will be vaccinated in the autumn and younger children in early 2022, and the UK is awaiting trial results to commence vaccination of 11 million children under 18. There is a lack of scientific justification for subjecting healthy children to experimental vaccines, given that the Centers for Disease Control and Prevention estimates that they have a 99.997% survival rate if infected with SARS-CoV-2. Not only is COVID-19 irrelevant as a threat to this age group, but there is no reliable evidence to support vaccine efficacy or effectiveness in this population or to rule out harmful side effects of these experimental vaccines. In this sense, when physicians advise patients on the elective administration of COVID-19 vaccination, there is a great need to better understand the benefits and risk of administration, particularly in understudied groups.

In conclusion, in the context of the rushed emergency-use-authorization of SARS-CoV-2 vaccines, and the current gaps in our understanding of their safety, the following questions must be raised:

  • Is it known whether cross-reactive antibodies from previous coronavirus infections or vaccine[1]206 induced antibodies may influence the risk of unintended pathogenesis following vaccination with COVID-19?
  • Has the specific risk of ADE, immunopathology, autoimmunity, and serious adverse reactions been clearly disclosed to vaccine recipients to meet the medical ethics standard of patient understanding for informed consent? If not, what are the reasons, and how could it be implemented?
  • What is the rationale for administering the vaccine to every individual when the risk of dying from COVID-19 is not equal across age groups and clinical conditions and when the phase 3 trials excluded the elderly, children and frequent specific conditions?
  • What are the legal rights of patients if they are harmed by a SARS-CoV-2 vaccine? Who will cover the costs of medical treatment? If claims were to be settled with public money, has the public been made aware that the vaccine manufacturers have been granted immunity, and their responsibility to compensate those harmed by the vaccine has been transferred to the tax-payers?

In the context of these concerns, we propose halting mass-vaccination and opening an urgent pluralistic, critical, and scientifically-based dialogue on SARS-CoV-2 vaccination among scientists, medical doctors, international health agencies, regulatory authorities, governments, and vaccine developers. This is the only way to bridge the current gap between scientific evidence and public health policy regarding the SARS-CoV-2 vaccines. We are convinced that humanity deserves a deeper understanding of the risks than what is currently touted as the official position. An open scientific dialogue is urgent and indispensable to avoid erosion of public confidence in science and public health and to ensure that the WHO and national health authorities protect the interests of humanity during the current pandemic. Returning public health policy to evidence-based medicine, relying on a careful evaluation of the relevant scientific research, is urgent. It is imperative to follow the science.

https://www.gov.uk/government/publications/covid-19-reported-sars-cov-2-deaths-in-england/covid-19-confirmed-deaths-in-england-report

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Figure legends