Preventing Dementia

Prevent Dementia

The updated Lancet Consortium on Dementia Prevention, published last year, concluded that 40 per cent of dementia cases could be prevented or delayed by targeting 12 modifiable risk factors, including obesity, type 2 diabetes, physical inactivity, excess alcohol intake and smoking.

Giving up smoking is particularly key, says Joanna Wardlaw, UK Dementia Research Institute group leader and a professor of applied neuroimaging at the Centre for Clinical Brain Science at Edinburgh University.

‘A natural part of the ageing process is that your brain tends to shrink a bit,’ she says, ‘and the more it shrinks, the more you are likely to have problems with cognitive ability.

‘Smoking causes accelerated thinning of parts of the brain, including the grey matter [which processes information]. If someone smokes from the age of 20 and gives up at 30, on average, someone who has never smoked won’t get the same level of damage to the grey matter until they’re 53.’

We all need to realise that the processes that cause dementia don’t just happen in old age, adds Professor Paul Matthews, a director of the UK Dementia Research Institute and head of the Department of Brain Sciences in the Faculty of Medicine at Imperial College London.

‘The FINGER study, which monitored 1,200 people in Finland at risk of cognitive decline [as a result of lifestyle factors such as lack of exercise and high blood pressure] found that interventions to help with diet, exercise and cognitive training significantly improved or maintained cognitive function,’ he says.

‘This was an important finding — the first reasonably large study in dementia to show that you could possibly reverse the progression of early phase cognitive performance loss, with interventions.’

A follow-up trial, METFINGER, is now being run in the UK and other international centres looking at providing lifestyle changes and adding in the diabetes drug metformin, which helps to lower blood sugar in the body.

‘The hypothesis is that metformin can tweak the ageing process of cells, including brain cells,’ says Professor Matthews. ‘It could have a similar effect to the impact statins have had on preventing cardiovascular disease.’

In addition to the usual lifestyle factors that we’re all advised to address, what other steps do the top dementia experts themselves take to ward off the disease? 

In bed by 10pm for a good night’s sleep 

Dr Ian Harrison, a senior research fellow at the Centre for Advanced Biomedical Imaging at University College London, who specialises in brain imaging, says: ‘When it comes to lowering my own dementia risk, I swear by a good night’s sleep. I used to go to bed later, but for the past three years I’ve been strict about going to bed at 10pm every day, even at weekends.

Dr Ian Harrison, a senior research fellow at the Centre for Advanced Biomedical Imaging at University College London, who specialises in brain imaging, says: ‘When it comes to lowering my own dementia risk, I swear by a good night’s sleep

‘The time I wake up depends on my children, aged one and three, but I set my bedtime early to give my brain the best chance to rest and have a clearout during the night.

‘The brain has a cleaning system, called the glymphatic system, which removes a build-up proteins and waste products.

‘We know from studies that the glymphatic system is 70 per cent more active when we sleep. If there is an impairment in the system due to lack of sleep, then this may lead to a build-up of proteins, including amyloid.

‘Anecdotally, we all know that we have a fuzzy head if we have a bad night’s sleep: this may be due to the glymphatic system not clearing out all the waste products.’

A review of studies by the University of Florida, published in the journal Sleep in 2017, followed up patients with sleep disorders, including obstructive sleep apnoea [where people stop breathing momentarily as they sleep], over nine and a half years and found a higher risk of them developing Alzheimer’s compared with those who had no sleep disturbances.

He says: ‘We know from studies that the glymphatic system is 70 per cent more active when we sleep’

Dr Harrison also makes sure he gets plenty of exercise.

‘We know from animal studies that exercise boosts the function of the glymphatic system,’ he says, ‘so I also go for a run and go to the gym every week, as well as cycling to work.’

Separately, but for the same reasons, Roger Watson, a professor of nursing at the University of Hull who works in care of older people, always switches off his phone at night. 

‘The light and potential buzzing can be disruptive to sleep — and studies suggest that broken sleep has an impact on our risk of dementia,’ he says. 

Chews on mints with xylitol 

Chris Fox, a professor of clinical psychiatry at the University of East Anglia Medical School, and a consultant old age psychiatrist at Norfolk and Suffolk NHS Foundation Trust, says: ‘As well as looking after my health generally, I take good care of my teeth to reduce the risk of dementia.

‘I use mints containing xylitol [an artificial sweetener] to keep the microbiome, the community of bacteria in the mouth, healthy.

‘This not only reduces dental cavities but xylitol actually gets rid of nasty bacteria, too. There is emerging evidence that it creates a healthier oral microbiome.

Chris Fox, a professor of clinical psychiatry at the University of East Anglia Medical School, and a consultant old age psychiatrist at Norfolk and Suffolk NHS Foundation Trust, says: ‘As well as looking after my health generally, I take good care of my teeth to reduce the risk of dementia’

‘One study from Bristol found the same bugs that can cause problems in the mouth were found in post-mortem brains of people who died from Alzheimer’s.’

(Note, xylitol in excess may cause bloating or diarrhoea in those with a sensitive gut.) One suggestion is that oral health may be linked to dementia as the bacteria may trigger inflammation in the brain.

The thinking is that porphyromonas gingivalis, the bacterium in the mouth that causes gum disease, crosses the blood brain barrier — a protective boundary between the bloodstream and the brain.

This can potentially alter brain cells, contributing to dementia, explains Karl Herholz, a professor in clinical neuroscience at Manchester University.

‘We know the disease begins around 20 to 30 years before symptoms become apparent, so it makes sense to have good oral health by brushing and visiting your dentist regularly, which I ensure I do to protect myself against dementia,’ he says. 

Avoids walking besides busy roads 

Dr Tom Russ, a consultant old age psychiatrist, director of the Alzheimer’s Scotland Dementia Research Centre, at the University of Edinburgh, says: ‘I make a conscious effort to avoid walking along main roads and find back street routes where possible’

Dr Tom Russ, a consultant old age psychiatrist, director of the Alzheimer’s Scotland Dementia Research Centre, at the University of Edinburgh, says: ‘I make a conscious effort to avoid walking along main roads and find back street routes where possible.’

Air pollution was added to the list of modifiable factors to reduce dementia by the Lancet Commission in 2020. This follows studies, including one in Canada of 6.6 million people, that have shown living on a main road is associated with a higher risk of dementia.

Those living within 50 metres of a major road were 7 per cent more likely to develop dementia than people living more than 300 metres away, where fine particulate matter levels [the particles of pollution that can get into the bloodstream] can be up to ten times lower.

‘Pollutant distribution depends on weather conditions, though,’ adds Dr Russ. Heatwaves and high pressure, for instance, can create stagnant air and pollutants are not dispersed — and winds can distribute pollutants over a wide area.

‘There are questions that remain unanswered about pollution and the brain, though. One is whether pollution is just a subtle effect on your thinking skills or does it have a structural effect on the brain.’

There is some suggestion that pollution contributes to brain inflammation, says Gill Livingston, a professor of mental health in older people at University College London. ‘My work is located near one of the most polluted roads in London, so if I walk there I drop back a street and walk parallel to the road, to avoid traffic.

‘It’s why it is also important to try to get away from pollution as much as possible, by spending leisure time or doing exercise in parks or in the countryside.’

She also avoids exposure to wood fires and passive smoking as both produce particulate matter. 


Professor Paul Matthews, a director of the UK Dementia Research Institute and head of the Department of Brain Sciences in the Faculty of Medicine at Imperial College London, says: ‘We’ve recently done a study that shows that there is an association between drinking alcohol and higher rates of brain volume loss.

‘In adults, the brain begins to lose half a teaspoon of its size [about 0.3 per cent of its volume] every year, and on average drinking two small glasses of wine a day doubles the rate of volume loss.

‘The base rate is low, though — doubling only increases the volume loss from 0.3 to 0.64 per cent. But we know people who experience more rapid rates of brain volume loss tend to develop more cognitive symptoms earlier than people who don’t have a rapid rate.

‘We have observed this association between alcohol and loss of brain volume in people who drank within the normal range (not excessively), though the effect was larger in those who drank heavily.

Eye & Ear Test

Has an eye test every year 

While it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked



While it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked

It’s now well-established that hearing loss — specifically, hearing loss when you don’t wear hearing aids if you need them — is a leading preventable cause of dementia, and addressing it could reduce the risk by 8 per cent, according to the Lancet Commission on dementia prevention.

Mild hearing loss doubled dementia risk, moderate hearing loss tripled it and severe hearing loss increased the risk by five times.

The theory is that not being able to hear well and the lack of social stimulation that follows is associated with a higher risk of brain shrinkage and damage.

But while it’s no surprise to learn that regular hearing tests — and wearing hearing aids when you need them — are key, Dr Emer MacSweeney, a former NHS consultant neuroradiologist and founder of Re:Cognition Health brain clinics, says it is also important to have your eyes checked.

‘The less well we hear — or lip read, which is key for our understanding of what’s being said — the less opportunity there is to have meaningful conversations that can stimulate the brain.

‘It’s why I make sure I have an eye test at least once a year. And if you think you might need glasses, you should see your optician.’ 

Doesn’t add salt when cooking 

Dr Sarah-Naomi James, a dementia research fellow at University College London, says: ‘Dementia doesn’t just happen in old age, it starts decades before’

Dr Sarah-Naomi James, a dementia research fellow at University College London, says: ‘Dementia doesn’t just happen in old age, it starts decades before. We now know that there is an association between high blood pressure [around 140/90 from midlife, roughly between the age of 40 and 50] and developing dementia.

‘I’m in my early 30s but I look after my physical health and I’m particularly careful about checking salt levels on packets. And I don’t add salt to food, either.

‘Blood pressure tends to rise with age, but there is something about what happens in mid-life that seems to be particularly important, although we don’t know what the mechanism is yet. One theory, though, is the pulsating pressure damages the brain.’ 

And deliberately uses ‘wrong’ hand 

Another step Dr MacSweeney takes is to try to put pressure on her brain by using her non-dominant hand for some tasks.

‘So as well as making sure I brush my teeth and use interdental brushes [to protect against mouth bacteria linked to dementia], I swap hands when using my toothbrush,’ she says. ‘Using the non-dominant hand can provide an additional workout for the brain.’

Similarly, she ‘supercharges’ her exercise regimen.

‘It’s well-recognised that exercise plays a role in helping reduce the risk of Alzheimer’s, with a 2019 study finding that aerobic exercise may specifically help combat changes in the brain associated with dementia,’ she says.

‘But research also tells us that you’ll get an even greater boost if you do a form of exercise that say, unlike jogging, makes you have to think about what you’re doing.

‘So as well as running, I do HIIT — high-intensity interval training — four to five times a week.

Work & Write in Two Languages

Carol Brayne (pictured) says: ”Our brains change quite a bit as we age, in the ways they are wired, and I think at the highest level our brains are meant to be stimulated’

Carol Brayne, a professor of public health at the University of Cambridge, says: ‘Studies have shown that factors such as social engagement, intellectual engagement, having a complex occupation and higher education are associated with a lower risk of dementia, although they don’t eradicate it completely.

‘Our brains change quite a bit as we age, in the ways they are wired, and I think at the highest level our brains are meant to be stimulated.

‘We know that from child development: if you don’t stimulate a child, their brain won’t develop.

‘We are organisms that respond to the environment, and we need stimulation in order to maintain things.

‘My message would be that you need to do things you enjoy, though. Enrich your life by taking up activities that you like and can become better at, at any life stage.

Science & Reason Publications by Dr Lalith Mendis

Covid Science Clips 100 – 187

  • 100 Happy Hour – WHO Weakens Nations 1 – Broken Relationship.-Dr.Lalith Mendis (03.11.2020)-
  • 103 Character & Curriculum – Balancing Calibration & Celebration In R Brain Kids For Exam Success.-
  • Covid Science 104 Two Camps -Shut Down Or Shield. HCQ Or No HCQ, Global or Nation.-Dr.Lalith Mendis-
  • Happy Hour 106-Five Digital Laws for Brain Bright & Heart Warm & Fruit by the river/barren by blight-
  • Science & Reason,Covid 107 – Debt Extractors & Debt Servicers- Globalist & Nation.-Dr.Lalith Mendis –
  • 108 Study On Screen – Keep Brain Bright. Sleep Well, Manage Under 5 yrs Well.-Dr.Lalith Mendis-
  • 110 Timely Thoughts Bread & Not Stones,Egg Not Scorpion, Fish Not Serpent.Invasion -Thief,Moth,Rust.-
  • 112 Covid – Pathology, Pharmacology, Early Treatment, Early Home Therapy, Swiss Epidemiology .-
  • Covid 113 – PCR Testing When & How. When False Positive.-Dr.Lalith Mendis (18.11.2020)-
  • 114 Dad Hero kallesthenics GARTS Grip & Rope Thrills To Make Kid Brain Brilliant.-Dr.Lalith Mendis-
  • 115 – Vaccines – Scientific Consideration For Laymen & Professionals.-Dr.Lalith Mendis (20.11.220)-
  • 118 PREVENTING DIGITAL BURNOUTCyber bullying,Curriculum,Career, Character Choices.DR.Lalith Mendis-
  • 120 Which Vaccine – Why Vaccine Furore – Every Child A Star.-Dr.Lalith Mendis (28.11.2020) –
  • 122 Covid Science – Run Up to the Rush Up – Spike Protein.-DR.Lalith Mendis (05.12.2020) –
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  • 126 Minding 7 tracts for 12 Health Systems – 7 H Hurt to hoard.-DR.Lalith Mendis (20.12.2020) –
  • 128 Twelve Social Genes that Made Thrillennials – Contest Generation.-DR.Lalith Mendis (23.12.2020) –
  • 130 Gift Or Prize – Fear To Favour. Self Critic – Defence Of A Depreciated Child.-DR.Lalith Mendis –
  • 131 7 Surfing Tips For Kids For Covid Times Improving 3AAA Rating.-DR.Lalith Mendis (27.12.2020) –
  • 133 Covid Update & QR Code for buy & sell. Covid immune reactions.-DR.Lalith Mendis (31.12.2020) –
  • 136 Triangle Of Power Victim Aggressor Elect-returning Nations To The Populace-CEO. .-DR.Lalith J Mendis –
  • 137 Covid Virus Update – Bears Growl & Doves Moan When Pharaohs Rule.DR. Lalith J Mendis(18.01.2021) –
  • 139 Ancient Ceylon Gold Rush WE Tennant Tarshish, Great Emporium Manthai.-DR.Lalith J Mendis –
  • 141 – GREAT REGRESS then we knew but now we slip – Looking for Fathers when malafiscence rules – horns butt, hoofs trample.- DR.Lalith J Mendis –
  • 142 Happy Gastronomics Saving GBU Good Bad Ugly Mixed Up Generation. Entertain Nixes Educate. –
  • 144Kids Home School Parents-Top Down Regulation අපේක්ෂා අරම්භය තරණය නිමාව Reward.DR.Lalith J Mendis –
  • Counsellers On Digital Toxicity & Addiction – Way Forward; Empathic Motor Therapy.-Dr.lalith Mendis –
  • 146 Training Customer is King Generation.පරිභෝජිකයා රජු පරපුර ශික්ෂණය.Dr.Lalith J Mendis(06.02.2021) –
  • 147 Digital addiction is gateway to other addictions – train for initiation navigation reward early – Top down regulation.-DR.Lalith J Mendis –
  •  148 Triology-Afraid,Naked,Hiding & 5 features of social pathogenesis -පරම්පරා විසන්දිය , ප්‍රතිකර්මය –
  • 149 Valentine day special – alcohol, sexual impulsivity -Wait makes taste great. Haste makes waste –
  • 150 Passing The Baton-7 Traits You Premiere & Pass On To Team-Run Life Alongside.DR.Lalith J Mendis –
  • 152 VIBGYOR for parents & kid training your tongue.Red says Remedy.Orange prepare.Dr.Lalith Mendis –
  • 153 Einstein’s WW IV – war against HMS HUMANITY – are we there.-DR.Lalith J Mendis (28.02.2021) –
  • 155 Harvest of Life – who is lord – seaon, seed bag, time of activation, relationships, placement, space of influence, opportunity, FINAL ACCOUNT.- DR.Lalith J Mendis (06.03.2021) –
  • 158 Sri Lanka Forgive Me & Save Us From The Stone Age Weapons.-Dr.Lalith Mendis (13.03.2021) –
  • 160 Covid Clots – Flattery Intoxicates, Xillennials, Train Brain & Brawn Together – 13 To 33 yrs . –
  • 162 Half Time when your tree of life transitions to an Orchard. Success to Legacy.-Dr.Laith J Mendis –
  • 165 Most Famour Kangaroo Court & Cardiac Tamponade – Injustice Is Finished.-DR.Lalith J Mendis –
  • 166 Dawn on Dark Night of my Soul, weapons of victimization, Bandaged Humanity.-Dr.Lalith J Mendis –
  • 169 Resurrection Hoax Or History Prof Anderson. Prof Oriental Law, Uni London Examines The Case. –
  • 170 Eng Tamil Sexuality Masculinity Femininity at 23,33,43 yrs half time வயதில் பாலியல்,ஆண்மை,பெண்மை –
  • 168 Eng Tam Crucifixion Earthquake Eclipse Kangaroo Court 1- சிலுவை அறைதல், பூமி அதிர்ச்சி, கிரகணம், கங்காரு நீதிமன்றம் 1.- DR.Lalith J MEndis (07.04.2021) –
  • 171 Life Wheel Romance & Stations Base 13, 23, 33, 43 Masculinity, femininity- අට චර්යා දිවි පත ප්‍රේමන්විතය සෞදර්‍ය සමපාත ලිංගිකත්වය
  • 172 Parents & Kids Train Champions – Mistake Manage To Fetch Them Forward – Catch Their GABA Time. –
  • ‘173 අවකාශ 8 – ජීවන චක්‍රය 8. ශ්‍රම ජීවිත තුලනය- வாஇடைவெளிகள்ழ்க்கை சக்கரம்- 8 – தொழில்சார்வாழ்கை. –
  • 174 Making Champions At 13, 23, 33, 43 yrs දෙමපියන් දූදරුවන් සූරයන් පුහුණු කිරීම අවු. 13,23,33,43 . –
  • 175 Eight Stations In Life – Romance Rules & Table Of Life, People & Provision.-DR.Lalith J Mendis –
  • 177 Age Gracefully Manifesto – Take Care Those Whom You Lead Will One Day Lead You – Home Or Work. –
  • 179 Covid Clot Update, Oxygen & Vitriol In The Mouth.-Dr.Lalith J Mendis (02.05.2021) –
  • 181 Prevention of Digital Burn Out – ඩිජිටල් ආධානය හා ධාහය වලකමු.-DR.Lalith J Mendis (07.05.2021) –
  • 182 Celebrate Mom – Recipe For Home. Motherhood – Last Bastion Of Civilization.-DR.Lalith J Mendis-
  • Mom The Last Bastion Of Civilization By Dr Lalith Mendis. Narration – Malaika Peiris –
  • 184 – Four Generational Wisdom For Refiring In Mature Years.-DR.Lalith J Mendis (11.05.2021) –
  • 186 Every Hour Counts For Sleep-When Gym Is Closed Or You’re Scared. Generational Connect 70 yrs 50 –

  • 101 දේශයේ අවමාන 1 – බිදුනු සබඳතා.-Dr.Lalith Mendis (03.11.2020)-
  • 102 ප්‍රභාශිත  ප්‍රාසාංගික දරු දෙවග පැවරුම හා සැමරුම Coaching Parents.-DR.Lalith Mendis (05.11.2020)-
  • 105 විද්වත් විමංසා -ගෝලීය දේශීය බල ගැටුම්,වෛරස , Vaccine.-DR.Lalith Mendis (08.11.2020) –
  • විද්වත් 109- පරම්පරා 3 අනුප්‍රාප්තිය – ලොව දිනන්නෝ,පුරුක් පරපුර,ලොව සොලවන්නෝ.-Dr.Lalith Mendis-
  • 111 සංකල්පනා වත්මන් කෝවිඩ් හා ගල් නොව රොටී,ගෝණුස්සකු නොව බිත්තර,සර්පයා නොව මළුව-උමං,කාවෝ,මලකඩ වලකමු.-
  • 116 Family Health- අභියෝගය,කෝවිඩ්,ක්‍රීඩා ගම්‍යතා Coach -තාත්තා වීරයා.-DR.Lalith Mendis (21.11.2020) –
  • 117 Do These 10 Ladders & Snakes Will Not Get Your Kids-තත්තා ළමුන් දිනවන Super Game 10.-
  • 119 – දෙමව්පියන් දිනූ කුසලානය-දූ දරුවෝ.-Dr.Lalith Mendis (27.11.2020) –
  • 121 Vaccine ක්‍රමවේද- විද්‍යාව ,ආර්ථිකය , රාජ්‍යතන්ත්‍රය.-Dr.Lalith Mendis (29.11.2020) –
  • 123 එන්නත් පවුල් සුරකුම ගෝලීය ප්‍රවනතා – වැටත් නියරත් ගොයම කෑ නම්.-DR.Lalith Mendis (09.12.2020)-
  • 127 පථ 7 හා  ශික්ෂා  7 – සෞඛ්‍ය පදනම 12.-DR.Lalith Mendis (20.12.2020)-
  • 129 – Bottom Up ලොවක් බිහි කළ සමාජ ජෙනෝමය සහ වත්මන් පරපුර 1990- 2020 අධිගාමී ප්‍රතිවාදී ත්‍රාසශීලී. –
  • 132 යතුරු 7 – 3AAA රටේ පවුල රකින මනෝ විද්‍යා ප්‍රඥා.-DR.Lalith Mendis (27.12.2020) –
  • 134 වන Covid කොවිඩ් යාවත්කාලීන කිරීම – අලුත් පුවත්, QR code, ගෝලීය පෙරලිය විද්‍යාව හා අවිද්‍යාව –
  •   135 බෙලහීන බලවන්ත අසාදාරන යමක් ත්‍රිකෝනය QUO VADIS-වරද කාගේද , කඩවුනු පොරොන්දුව.-DR.Lalith J Mendis –
  • 138 කෝවිඩ් Update අළුත් වෛරස් ප්‍රබේද ප්‍රතිශක්ති ඌනතා- වැට නියර ගොයම් කන විට.-DR.Lalith J Mendis –
  • 140-Covid Spike Protein වෙනුවට අළුත් ඖෂධ ආවේ පුරාණ රත්රන් වෙරළ Ancient Ceylon වලසුන් හා පරවියන්.
  • 143 කුරිරු ගොර සපුන් වූ අවිද්‍යා – අධ්‍යාපන පරදවන අවිචාරය හා ළමුන්.-Dr.Lalith J Mendis (28.01.2021) –
  • 143-7 Tracts Prophecy,Serve Teach Barnabas Invest Lead Mercyමනෝරූප සේවා ගුරු පුහුණු ආයෝජක නායක කරුන –
  • මනෝරූප සේවා ගුරු පුහුණු ආයෝජක නායක කරුන.-Dr.Lalith J Mendis –
  • 151 පරම්පරා ප්‍රගමනය- වත්මන් වතගොත කපුටු කාක් චරිතාංග 7 ප්‍රශ්න 7 .-DR.Lalith J Mendis (20.02.2021) –
  • 154 අයින්ස්ටයින්ගේ 4 වන ලෝක මහා සංග්‍රාමය එළු බැටලු යුද්ධය ගෝලීය අක්‍රමන.-DR.Lalith J Mendis –
  • 156 ජීවන අස්වැන්නේ- වවමුද ? කමුද ? උල හෝ පිල .කටු වගා ඵල යට කරයිද ?.-DR.Lalith J Mendis (06.03.2021) –
  • ජීවන අස්වැන්න | Episode 156 –
  • 159 ශ්‍රී ලංකා සමා වෙන්න පාෂාණ යුගයේ ගල් ආයුධ වලින් ගලවා ගන්නේ.-Dr.Lalith Mendis (13.03.2021) –
  • 161 ලොව වනසන දූෂ්‍ය ප‍්‍රඥා 12 අභිබවා චාරික මාලිමාවක් ඇත Moral Magnetism vs Corrupt Wisdom. –
  • 163 ජීවිත අස්වැන්නේ අවුරුදු 33 – 43. 43න් එහා නොනිමි පහන.-Dr.Laith J Mendis (28.03.2021) –
  • 164 අසාධාරණය රජ කල සිකුරාදා නඩු විභාගය – පොලව පැලුනු වගයි- Kangaroo Court-Cardiac Tamponade. –
  •  167 යුගාංතික සංග්‍රාමය නිරායුද සම්මුතිය.-DR.Lalith J Mendis (04.04.2021) –
  • 176 ජීවිත සිතුවම Life Map & Table – ජීවන මේසය අට කාරක – අටකාරක සමෘද්ධිය.-DR.Lalith J Mendis –
  • 178 වියපත් ස්වර්ණමය සැන්දෑවේ- දිවි ලිද ලග බොලොක්කය බිදෙන දින.-DR.Lalith J Mendis (19.074.2021) –
  • 180 කෝවිඩ් ඔක්සිජන් මගේ මුව හුස්ම හිර නොකරයි.-Dr.Lalith J Mendis (02.05.2021) –
  • 183 මාතෘත්වය සමරමු – තොටිල්ල නලවන අත .-DR.Lalith J Mendis (07.05.2021) –
  • 187 අපේක්ෂා පූර්ණ පායෙන පැය DMN නෙට්වර්ක් ගෙදරම ජිම් අභ්‍යාස .කොවිඩ් පරදන චරිතාංග 7. –

Analysis by 57 Scientists of Pharmacology & Immunology

Analysis by 57 Scientists of Pharmacology & Immunology

Roxana Bruno1, Peter McCullough2, Teresa Forcades i Vila3, Alexandra Henrion-Caude4, Teresa García-Gasca5, Galina P. Zaitzeva6, Sally Priester7, María J. Martínez Albarracín8, Alejandro Sousa-Escandon9, Fernando López Mirones10, Bartomeu Payeras Cifre11, Almudena Zaragoza Velilla10, Leopoldo M. Borini1, Mario Mas1, Ramiro Salazar1, Edgardo Schinder1, Eduardo A Yahbes1, Marcela Witt1, Mariana Salmeron1, Patricia Fernández1, Miriam M. Marchesini1, Alberto J. Kajihara1, Marisol V. de la Riva1, Patricia J. Chimeno1, Paola A. Grellet1, Matelda Lisdero1, Pamela Mas1, Abelardo J. Gatica Baudo12, Elisabeth Retamoza12, Oscar Botta13, Chinda C. Brandolino13, Javier Sciuto14, Mario Cabrera Avivar14, Mauricio Castillo15, Patricio Villarroel15, Emilia P. Poblete Rojas15, Bárbara Aguayo15, Dan I. Macías Flores15, Jose V. Rossell16, Julio C. Sarmiento17, Victor Andrade-Sotomayor17, Wilfredo R. Stokes Baltazar18, Virna Cedeño Escobar19, Ulises Arrúa20, Atilio Farina del Río21, Tatiana Campos Esquivel22, Patricia Callisperis23, María Eugenia Barrientos24, Karina Acevedo-Whitehouse5,*

SARS-CoV-2 mass vaccination: Urgent questions on vaccine safety that demand answers from international health agencies, regulatory authorities, governments and vaccine developers

1Epidemiólogos Argentinos Metadisciplinarios. República Argentina.
2Baylor University Medical Center. Dallas, Texas, USA.
3Monestir de Sant Benet de Montserrat, Montserrat, Spain
4INSERM U781 Hôpital Necker-Enfants Malades, Université Paris Descartes-Sorbonne Cité, Institut Imagine, Paris, France.
5School of Natural Sciences. Autonomous University of Querétaro, Querétaro, Mexico.
6Retired Professor of Medical Immunology. Universidad de Guadalajara, Jalisco, Mexico.
7Médicos por la Verdad Puerto Rico. Ashford Medical Center. San Juan, Puerto Rico.
8Retired Professor of Clinical Diagnostic Processes. University of Murcia, Murcia, Spain
9Urologist Hospital Comarcal de Monforte, University of Santiago de Compostela, Spain.
10Biólogos por la Verdad, Spain.
11Retired Biologist. University of Barcelona. Specialized in Microbiology. Barcelona, Spain.
12Center for Integrative Medicine MICAEL (Medicina Integrativa Centro Antroposófico Educando en Libertad). Mendoza, República Argentina.


Since the start of the COVID-19 outbreak, the race for testing new platforms designed to confer immunity against SARS-CoV-2, has been rampant and unprecedented, leading to emergency authorization of various vaccines. Despite progress on early multidrug therapy for COVID-19 patients, the current mandate is to immunize the world population as quickly as possible. The lack of thorough testing in animals prior to clinical trials, and authorization based on safety data generated during trials that lasted less than 3.5 months, raise questions regarding the safety of these vaccines. The recently identified role of SARS-CoV-2 glycoprotein Spike for inducing endothelial damage characteristic of COVID-19, even in absence of infection, is extremely relevant given that most of the authorized vaccines induce the production of Spike glycoprotein in the recipients. Given the high rate of occurrence of adverse effects, and the wide range of types of adverse effects that have been reported to date, as well as the potential for vaccine-driven disease enhancement, Th2-immunopathology, autoimmunity, and immune evasion, there is a need for a better understanding of the benefits and risks of mass vaccination, particularly in the groups that were excluded in the clinical trials. Despite calls for caution, the risks of SARS-CoV-2 vaccination have been minimized or ignored by health organizations and government authorities. We appeal to the need for a pluralistic dialogue in the context of health policies, emphasizing critical questions that require urgent answers if we wish to avoid a global erosion of public confidence in science and public health.


Since COVID-19 was declared a pandemic in March 2020, over 150 million cases and 3 million deaths have been reported worldwide. Despite progress on early ambulatory, multidrug-therapy for high-risk patients, resulting in 85% reductions in COVID-19 hospitalization and death [1], the current paradigm for control is mass-vaccination. While we recognize the effort involved in development, production and emergency authorization of SARS-CoV-2 vaccines, we are concerned that risks have been minimized or ignored by health organizations and government authorities, despite calls for caution [2-8].

Vaccines for other coronaviruses have never been approved for humans, and data generated in the development of coronavirus vaccines designed to elicit neutralizing antibodies show that they may worsen COVID-19 disease via antibody-dependent enhancement (ADE) and Th2 immunopathology, regardless of the vaccine platform and delivery method [9-11]. Vaccine-driven disease enhancement in animals vaccinated against SARS-CoV and MERS-CoV is known to occur following viral challenge, and has been attributed to immune complexes and Fc-mediated viral capture by macrophages, which augment T-cell activation and inflammation [11-13].

In March 2020, vaccine immunologists and coronavirus experts assessed SARS-CoV-2 vaccine risks based on SARS-CoV-vaccine trials in animal models. The expert group concluded that ADE and immunopathology were a real concern, but stated that their risk was insufficient to delay clinical trials, although continued monitoring would be necessary [14]. While there is no clear evidence of the occurrence of ADE and vaccine-related immunopathology in volunteers immunized with SARS-CoV-2 vaccines [15], safety trials to date have not specifically addressed these serious adverse effects (SAE). Given that the follow-up of volunteers did not exceed 2-3.5 months after the second dose [16-19], it is unlikely such SAE would have been observed. Despite92 errors in reporting, it cannot be ignored that even accounting for the number of vaccines administered, according to the US Vaccine Adverse Effect Reporting System (VAERS), the number of deaths per million vaccine doses administered has increased more than 10-fold. We believe there is an urgent need for open scientific dialogue on vaccine safety in the context of large-scale immunization. In this paper, we describe some of the risks of mass vaccination in the context of phase 3 trial exclusion criteria and discuss the SAE reported in national and regional adverse effect registration systems. We highlight unanswered questions and draw attention to the need for a more cautious approach to mass vaccination.

SARS-CoV-2 phase 3 trial exclusion criteria

With few exceptions, SARS-CoV-2 vaccine trials excluded the elderly [16-19], making it impossible to identify the occurrence of post-vaccination eosinophilia and enhanced inflammation in elderly people. Studies of SARS-CoV vaccines showed that immunized elderly mice were at particularly high risk of life-threatening Th2 immunopathology [9,20]. Despite this evidence and the extremely limited data on safety and efficacy of SARS-CoV-2 vaccines in the elderly, mass-vaccination campaigns have focused on this age group from the start. Most trials also excluded pregnant and lactating volunteers, as well as those with chronic and serious conditions such as tuberculosis, hepatitis C, autoimmunity, coagulopathies, cancer, and immune suppression [16-29], although these recipients are now being offered the vaccine under the premise of safety.

Another criterion for exclusion from nearly all trials was prior exposure to SARS-CoV-2. This is unfortunate as it denied the opportunity of obtaining extremely relevant information concerning post-vaccination ADE in people that already have anti-SARS-Cov-2 antibodies. To the best of our knowledge, ADE is not being monitored systematically for any age or medical condition group currently being administered the vaccine. Moreover, despite a substantial proportion of the population already having antibodies [21], tests to determine SARS-CoV-2-antibody status prior to administration of the vaccine are not conducted routinely.

Will serious adverse effects from the SARS-CoV-2 vaccines go unnoticed?

COVID-19 encompasses a wide clinical spectrum, ranging from very mild to severe pulmonary pathology and fatal multi-organ disease with inflammatory, cardiovascular, and blood coagulation dysregulation [22-24]. In this sense, cases of vaccine-related ADE or immunopathology would be clinically-indistinguishable from severe COVID-19 [25]. Furthermore, even in the absence of SARS-CoV-2 virus, Spike glycoprotein alone causes endothelial damage and hypertension in vitro and in vivo in Syrian hamsters by down-regulating angiotensin-converting enzyme 2 (ACE2) and impairing mitochondrial function [26]. Although these findings need to be confirmed in humans, the implications of this finding are staggering, as all vaccines authorized for emergency use are based on the delivery or induction of Spike glycoprotein synthesis. In the case of mRNA vaccines and adenovirus-vectorized vaccines, not a single study has examined the duration of Spike production in humans following vaccination. Under the cautionary principle, it is parsimonious to consider vaccine-induced Spike synthesis could cause clinical signs of severe COVID-19, and erroneously be counted as new cases of SARS-CoV-2 infections. If so, the true adverse effects of the current global vaccination strategy may never be recognized unless studies specifically examine this question. There is already non-causal evidence of temporary or sustained increases138 in COVID-19 deaths following vaccination in some countries (Fig. 1) and in light of Spike’s pathogenicity, these deaths must be studied in depth to determine whether they are related to vaccination.

Unanticipated adverse reactions to SARS-CoV-2 vaccines

Another critical issue to consider given the global scale of SARS-CoV-2 vaccination is autoimmunity. SARS-CoV-2 has numerous immunogenic proteins, and all but one of its immunogenic epitopes have similarities to human proteins [27]. These may act as a source of antigens, leading to autoimmunity [28]. While it is true that the same effects could be observed during natural infection with SARS-CoV-2, vaccination is intended for most of the world population, while it is estimated that only 10% of the world population has been infected by SARS-CoV-2, according to Dr. Michael Ryan, head of emergencies at the World Health Organization. We have been unable to find evidence that any of the currently authorized vaccines screened and excluded homologous immunogenic epitopes to avoid potential autoimmunity due to pathogenic priming.

Some adverse reactions, including blood-clotting disorders, have already been reported in healthy and young vaccinated people. These cases led to the suspension or cancellation of the use of adenoviral vectorized ChAdOx1-nCov-19 and Janssen vaccinesin some countries. It has now been proposed that vaccination with ChAdOx1-nCov-19 can result in immune thrombotic thrombocytopenia (VITT) mediated by platelet-activating antibodies against Platelet factor-4, which clinically mimics autoimmune heparin-induced thrombocytopenia [29]. Unfortunately, the risk was overlooked when authorizing these vaccines, although adenovirus-induced thrombocytopenia has been known for more than a decade, and has been a consistent event with adenoviral vectors [30]. The risk of VITT would presumably be higher in those already at risk of blood clots, including women who use oral contraceptives [31], making it imperative for clinicians to advise their patients accordingly.

At the population level, there could also be vaccine-related impacts. SARS-CoV-2 is a fast-evolving RNA virus that has so far produced more than 40,000 variants [32,33] some of which affect the antigenic domain of Spike glycoprotein [34,35]. Given the high mutation rates, vaccine-induced synthesis of high levels of anti-SARS-CoV-2-Spike antibodies could theoretically lead to suboptimal responses against subsequent infections by other variants in vaccinated individuals [36], a phenomenon known as “original antigenic sin” [37] or antigenic priming [38]. It is unknown to what extent mutations that affect SARS-CoV-2 antigenicity will become fixed during viral evolution [39], but vaccines could plausibly act as selective forces driving variants with higher infectivity or transmissibility. Considering the high similarity between known SARS-CoV-2 variants, this scenario is unlikely [32,34] but if future variants were to differ more in key epitopes, the global vaccination strategy might have helped shape an even more dangerous virus. This risk has recently been brought to the attention of the WHO as an open letter [40].


The risks outlined here are a major obstacle to continuing global SARS-CoV-2 vaccination. Evidence on the safety of all SARS-CoV-2 vaccines is needed before exposing more people to the184 risk of these experiments, since releasing a candidate vaccine without time to fully understand the resulting impact on health could lead to an exacerbation of the current global crisis [41]. Risk-stratification of vaccine recipients is essential. According to the UK government, people below 60 years of age have an extremely low risk of dying from COVID-191 187 . However, according to Eudravigillance, most of the serious adverse effects following SARS-CoV-2 vaccination occur in people aged 18-64. Of particular concern is the planned vaccination schedule for children aged 6 years and older in the United States and the UK. Dr. Anthony Fauci recently anticipated that teenagers across the country will be vaccinated in the autumn and younger children in early 2022, and the UK is awaiting trial results to commence vaccination of 11 million children under 18. There is a lack of scientific justification for subjecting healthy children to experimental vaccines, given that the Centers for Disease Control and Prevention estimates that they have a 99.997% survival rate if infected with SARS-CoV-2. Not only is COVID-19 irrelevant as a threat to this age group, but there is no reliable evidence to support vaccine efficacy or effectiveness in this population or to rule out harmful side effects of these experimental vaccines. In this sense, when physicians advise patients on the elective administration of COVID-19 vaccination, there is a great need to better understand the benefits and risk of administration, particularly in understudied groups.

In conclusion, in the context of the rushed emergency-use-authorization of SARS-CoV-2 vaccines, and the current gaps in our understanding of their safety, the following questions must be raised:

  • Is it known whether cross-reactive antibodies from previous coronavirus infections or vaccine[1]206 induced antibodies may influence the risk of unintended pathogenesis following vaccination with COVID-19?
  • Has the specific risk of ADE, immunopathology, autoimmunity, and serious adverse reactions been clearly disclosed to vaccine recipients to meet the medical ethics standard of patient understanding for informed consent? If not, what are the reasons, and how could it be implemented?
  • What is the rationale for administering the vaccine to every individual when the risk of dying from COVID-19 is not equal across age groups and clinical conditions and when the phase 3 trials excluded the elderly, children and frequent specific conditions?
  • What are the legal rights of patients if they are harmed by a SARS-CoV-2 vaccine? Who will cover the costs of medical treatment? If claims were to be settled with public money, has the public been made aware that the vaccine manufacturers have been granted immunity, and their responsibility to compensate those harmed by the vaccine has been transferred to the tax-payers?

In the context of these concerns, we propose halting mass-vaccination and opening an urgent pluralistic, critical, and scientifically-based dialogue on SARS-CoV-2 vaccination among scientists, medical doctors, international health agencies, regulatory authorities, governments, and vaccine developers. This is the only way to bridge the current gap between scientific evidence and public health policy regarding the SARS-CoV-2 vaccines. We are convinced that humanity deserves a deeper understanding of the risks than what is currently touted as the official position. An open scientific dialogue is urgent and indispensable to avoid erosion of public confidence in science and public health and to ensure that the WHO and national health authorities protect the interests of humanity during the current pandemic. Returning public health policy to evidence-based medicine, relying on a careful evaluation of the relevant scientific research, is urgent. It is imperative to follow the science.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


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Figure legends

Age Gracefully Manifesto – 45 yr old & 75 yr old Tango Together

 Age Gracefully Manifesto (AGM) to a Good Plan

Dr Lalith Mendis

Let’s make seniors look forward to old age. I am wondering if people hate old age? This can have ripple effects. Your old age becomes insecure. Kids don’t care – especially in a culture they took their future into their hands to seek greener pastures elsewhere, never to return. Then seniors pretend they don’t want to burden their progeny – is this a kind of crying over spilt milk.

Then people defy old age by activism. Is this good or bad? When long deferred & ultimately old age “hits”, will it unravel you?

Grandkids save seniors from Alzheimer!!

Ecc 12:1  Remember also your Creator in the days of your youth, before the evil days come and the years draw near when you will say, “I have no delight in them”;

Preacher envisages that old age will be a time without delight in the dawning day. The Blessing Manifesto that follows attempts to keep delight in your day as you age.

Work, Family, Church – Training others to take over more of what you do, can be gainful entry into Sunset of life. Let’s age gracefully. In training we run slower, but grow deeper. Don’t hold on to the helm, until all hope for your disappearance. Let up gradually. So they see a senior less vigorous but more amiable & available. Your succession finds you, well employed, “under” them. You are there to help them when they are in the driving seat – protecting their back & providing them with a spare wheel, which is you. Your wisdom will be long valued when you wait till they need it.

Larger Space for Next Generation

It is time for seniors to provide room for next generation without further delay. They are asking to build their style. Elisha was wise to say – Go. They also said you pl come with us. What a great succession. Not that they went with Elisha but that Elisha went with them. This is generational succession & Legacy – transition.

2Ki 6:3-4  Then one said, “Please be willing to go with your servants.” And he answered, “I shall go.”  (4)  So he went with them; and when they came to the Jordan, they cut down trees.

When they ran into axe head problems, senior was there to pick it up for them. Not enough space for next gen at all levels may be our problem.

How do you know you are a senior?

  1. Almost all of your decisions are made by others. You only follow them
  2. So cultivate early, good relationships with people, who will take over decision making from you.
  3. Since you taught them how to decide, it should be easy to follow their decisions. This includes your posterity & your colleagues
  4. So make your decisions when you are powerful, with truth, mercy, humility & sensitivity. Tell your kids & colleagues why & how you make those just & compassionate decisions
  5. Remember that’s going to serve you well when you are at the receiving end of their decisions. This includes your posterity & your colleagues

Golden Sunset Manifesto

Lord is addressing all the difficulties you encounter as you age

  1. Get ready in the morning, wash up & dress up as if you are going to sweep clean to the extent you can. Make a time table hour to hour of simple doables.
  2. Your fear of heights he removes. Your son will provide a room on ground floor, so that you need not fear inability to climb stairs
  3. Your daughter will take care of you in their own home. God will give seniors a spirit of contentment rather than demand
  4. We bless you with good relationships with son in law & daughter in law. You will yet be useful.
  5. Write 4 pages handwriting in two languages as long as you can. You delay Alzheimer. Shift completely to read printed stuff – wean off screen. This screen time trap can prove costly
  6. Lord will halt all disabilities, so you will have enough functionality in every joint,
  7. O Lord let not ill effects of Diabetes, hypertension trouble your saints in their old age
  8. O Lord Grant them reasonable hearing & eye sight.
  9. You will have functionality in Every vital organ – heart, brain & kidney
  10. You will have no obstruction in the urinary system,
  11. We prohibit cancer. O Lord let the immune system be strong to swallow up any cancer cell.
  12. We don’t want Alzheimer of failing memory.
  13. Your organs will not fail before your departure & entry into glory
  14. You are an elder statesman in life & in Christ. Be assured of your identity, worth & significance. These issues matter in all seasons, but more so when you are likely to feel, “no one wants me much, nowadays.” 
  15. You will have no fear of desolation, disappointment, depression, distress, loneliness, deprivation,
  16. You will have no family disputes, no land disputes, no court cases, no debt,
  17. No thief will break into your home. No fraud will get at your finances.
  18. You are getting ready for a golden sunset – your smile is returning. You will be surrounded by the friends whom you cultivated all your life
  19. You will wake up well rested, in readiness do whatever work you have to do. It’s the gift of God. You will have a pleasant afternoon rest. Hours will, not hang around you. Gardening & a pet may come in as useful exercise.
  20. Grand children will be a great boon around you. You will even be vibrant in brain doing home work with them.
  21. You will have sound sleep, good rest, no agitation, no unpleasant surprises, enjoy kindness on every side, dispense forgiveness
  22. Agree with spouse about romance & sex life. Even at 80 yrs, men like physical sex. Since the wife will get feeble, reduce the
  23. Your departure will be to enter portals of glory. Last years of life prepares you for glory – where there is gentleness, mellowness, melody.

Manly Men Parenting & Helicopter Parenting


Parents who are overprotective are sometimes referred to as ‘helicopter parents’. 

They earned this stereotype for being perceived as relentlessly hovering over their children, trying to micro-manage their affairs. 

The first use of the term is widely attributed to Dr Haim Ginott’s 1969 book Parents & Teenagers. 

In it, teens said their parents would hover over them like a helicopter.

The term became popular enough to become a dictionary entry in 2011.

Helicopter parents pay extremely close attention to their children to try to protect them from failure, rejection and injury. 

They want ‘happy’ children and often believe that teachers should pay attention to their children in the same overprotective way.

This approach has sparked controversy, with some experts arguing that in order for children to become well adjusted, they need to experience a full range of emotions. 

Parents who want their children to always be happy are doing their children a disservice, in this view.  

The ‘helicopter’ parent rushes in to help rather than allowing their child to have a go at managing a challenging situation themselves.

Some experts say that this can lead to children who are unable to cope with even minor issues, as they are never given the opportunity to fail and then learn from their mistakes.

However, some experts suggest that such ‘pushy’ parenting may provide children with benefits in later life.

Among them is Dr Matthias Doepke, a professor of economics in the Weinberg College of Arts and Sciences at Northwestern University.

He argues that the intensity of parenting has gone up in many countries in line with rising inequality.

Pushy ‘helicopter’ parents, normally from more economically advantaged backgrounds, generally raising higher achieving offspring.

Gender Synergy

Masculinity & Femininity are reciprocal.

Man is supposed to lead in certain areas & woman will receive. Woman leads in other areas for man to receive. Closest to perfect love is what mom feels for baby in the womb. She risks her life to birth him. Even is there was life threatening Eclampsia, she would be reluctant to allow therapeutic abortion.

From about the third month of the pregnancy, wife begins to lead home. This is because her need is priority. All in the home – meals, time, sanitary patterns, sleep time – all are set for her convenience. She begins to lead the husband in welcoming baby into their life. Husband has to sacrifice sexual life & attend to her needs. He will be initially grumpy. He has to shoulder in some physical work. He overcomes the displeasure at these discomforts & bonds with the child in the womb, under the leadership of the wife. It’s crunch time for long term bonding in marriage. Those who delay pregnancy will not be consolidating marital covenant & look to wife leading life during this critical period. Wife’s strenuous labour process makes her leader in all this. Whoever sacrifices more leads, is how life happens.

When God spliced Adam in two, He did adjustments to Adam & Eve – Adam to need helpmeet (Gk paracletos) & woman to need him. So we grow into each other’s spaces in marriage & that helps us to understand discipleship process.

Masculinity needs femininity in right balance. Where He leads she receives. Where she leads he receives. Know your roles for maximum growth. Passing 40 yrs hubby will learn more & more to serve. Passing 40 yrs, wife needs to temper her mood – knowing mood swings & stresses are due. Be helpful to one another. May your door of grace & life grow together wider & taller. On that door depends how provided & spacious your room in life will be. It’s worth all the effort. You are not only providing for yourself, you are providing for next generation – success to significance. Winning all alone to win for all

When the man does not make room for the woman to grow

  1. He does not receive the equal help of two trunks growing as one tree
  2. She will manhandle what she needs to woman-handle
  3. Gen 1:28 was for both to execute – so the divergence will make each one less than full = frustration.
  4. She is not a creeper wrapping around him, but a valid tree, growing with him – conjoined.
  5. When he has not been her “life” (=kinsman redeemer), she will increasingly look to earth, though her name is mother of life =Eve
  6. Kids would get S-mothered rather than parented
  7. At 40 yrs be alert re unguarded sexual impulses – Bathsheba moments. At 43 yrs we must take stock. Wife has sacrificed all she can & she enters the vulnerable age of mood swings & hormonal changes. This is the time she needs most help.
  8. Being loved has much to do with sexual intimacy. Never let up on this. Yet in this too, it’s more blessed to give than get. This should be the man’s mindset. Not a right to grab.
  9. By 55 yrs, when kids are strong, she will think, he was never there for me, why do I need him now. So, be sensitive when passing 43 yrs.
  10. Worse still, she may find satisfaction & fulfilment elsewhere – sexually or socially.

Great Regress – once we knew but now we don’t know…

  1.  If baby in the womb is a person with right to life, but we will fight to save whales
  2.  If XX & XY determines boy or girl or if child must chose
  3.  Who must make marriage & family – XX/XY or XX/XX or XY/XY or XX/XY/XX or any number of diverse combines
  4. Dad & mom care for kids at home
  5. If we make marriage for life or for season
  6.  That in one country we do generations passing on legacy & baton
  7.  We should care for our elders & not leave it to the state
  8.  That vaccines must prevent infection
  9.  If medical scientists know what they recommend
  10.  If our legislators have our best interest in their heart
  11.  If our Professionals are benefactors or malefactors, mala fide or bona fide
  12. If international law is for citizen’s good or for global control
  13. If raw data of our gold standard clinical trials support published stratified statistics
  14. Lockdown is bad for health

HMS Earthship

For the Ship of Human Life, rail guards for protection & Anchor weights for stability were Designed, as HMS Humanity moved thru the generations. Many ships from former generations docked in at the Port of Final Call on the Sands of Time. Rail guards & anchorage were…

  1. Sanctity of Marriage
  2. Safety & Stability of Sexuality
  3. Sanctity of Unborn Life
  4. Family members grow together – don’t become aliens
  5. Custody of Elders
  6. Equal protection for handicapped
  7. Special provision for poor – food, health, education for all.
  8. Immunity for body
  9. National Economies to be answerable to local populace
  10. Equal protection under the Law with a Government of the people, by the people, for the people –not by global elite for elite.

Statins & Jupiter Trial

Flaws of Jupiter Study

Now, however, researchers behind a new review that takes a second look at the findings of the landmark Jupiter study say that these results are flawed — and that they do not support the benefits initially reported.

Not only did this second look turn up no evidence of the “striking decrease in coronary heart disease complications” reported by investigators behind JUPITER (Justification for the Use of Statins in Primary Prevention), but it has also called into question drug companies’ involvement in such trials, according to an article in the June 28 issue of Archives of Internal Medicine.

Moreover, Dr. Michel de Lorgeril of Joseph Fourier University and the National Center of Scientific Research in Grenoble, France, and coauthors argue that major discrepancies exists between the significant reductions in nonfatal stroke and heart attacks reported in the JUPITER trial and what has been found in other research.

“The JUPITER data set appears biased,” Lorgeril and coauthors wrote in conclusion.

Dr. Paul Ridker of Harvard Medical School and Brigham and Women’s Hospital in Boston dismissed de Lorgeril’s criticisms. Ridker reported the JUPITER results at the American Heart Association meeting in 2008.

A group of researchers behind a new review that takes a second look at the findings of the landmark JUPITER study say that the original results are flawed.

In an email to MedPage Today, Ridker said that JUPITER data “overwhelmingly stand for themselves. Among a group of individuals with low levels of cholesterol, we clearly demonstrate that those with elevated levels of [the inflammation marker] hsCRP are in fact a high-risk population, and that using statin therapy in this group cuts event rates for [heart attack] and stroke in half.”

Ridker also pointed out that the “FDA has extensively reviewed these data, found the trial to be well conducted, and recently provided a new indication for the use of statins in primary prevention on the basis of the JUPITER data.”

AstraZeneca, maker of the popular statin Crestor (known generically as rosuvastatin), also defended the JUPITER results and the way in which the study was conducted.

Donna Huang, an AstraZeneca spokesperson, told MedPage Today in an email that the study “was undertaken with a fully independent steering committee, data and safety monitoring board, and academic study statistician.”

She also said Ridker and his co-investigators controlled all data. “AstraZeneca played no role in conducting data analyses and had no access to unblinded trial data,” she wrote.

De Lorgeril and coauthors point out that nine of 14 authors of the JUPITER article have financial relationships with AstraZeneca, which sponsored the trial. Ridker has a patent interest in the assay for C-reactive protein (CRP), an inflammation biomarker evaluated in all JUPITER trial participants.

“The sponsor’s pervasive role is clearly described in the second paragraph of the ‘Methods’ section of the report: ‘the sponsor collected the trial data and monitored the study sites,’” the authors wrote.

De Lorgeril and coauthors concluded that “the results of the JUPITER trial are clinically inconsistent and therefore should not change medical practice or clinical guidelines. The results of the JUPITER trial support concerns that commercially sponsored clinical trials are at risk of poor quality and bias.”

Adding to the controversy, authors of another article in the same issue of Archives reported that a review of 11 large primary-prevention trials showed no effect of statin therapy on deaths in high-risk patients.

The JUPITER trial has stood alone in its finding of a significant benefit in patients with no evidence of coronary heart disease. The trial examined the effect of rosuvastatin in patients with normal or low cholesterol levels but elevated levels of CRP.

Investigators randomized 17,802 apparently healthy men and women to receive either the statin rosuvastatin or a placebo, and then they studied these groups to compare how many suffered heart attacks, strokes and other heart-related problems. The trial ended early when an interim analysis showed a 44 percent reduction in these events in the group taking the statins; with results this positive, the logic went, why continue the study?

But de Lorgeril and his coauthors cited the early termination as one of several methodologic problems with JUPITER. Although prespecified early stopping points are a well-accepted feature of clinical trials, the rules for stopping should be clearly described. That was not the case in the published description of the JUPITER protocol.

“Indeed, we still do not know which endpoint was used to define [the rules for stopping], or which level of benefits … was required to justify early termination,” de Lorgeril and coauthors wrote.

The authors also expressed concern that the trial ended early despite the fact that the data were not consistent with a large difference between the actual drug and the placebo.

On the basis of their review, de Lorgeril and coauthors concluded that “the time has come for a critical reappraisal of cholesterol-lowering and statin treatments for the prevention of CHD complications. The emphasis on pharmaceuticals for the prevention of CHD diverts individual and public health attention away from the proven efficacy of adopting a healthy lifestyle, including regular physical activity, not smoking, and a Mediterranean-style diet.”

The meta-analysis reported in the same issue of the journal, led by Dr. Kausik Ray of the University of Cambridge in England, examined the findings of 11 randomized clinical trials involving a total of 65,229 patients to see if statins cut death rates among intermediate and high-risk people with no history of cardiovascular disease. In this study, too, the support for statin use was lacking.

  • One in four Americans are now taking a statin drug, despite the fact that there are over 900 studies proving their adverse effects, which run the gamut from muscle problems to diabetes and increased cancer risk.
  • Statins deplete your body of CoQ10, which can have devastating results. If you take statin drugs without taking CoQ10, your health is at serious risk. If you have symptoms of statin damage such as muscle pain, take anywhere from 200 to 500 mg of CoQ10 or ubiquinol, which is the reduced form. Ubiquinol is the recommended form if you’re over the age of 25. For preventative use, take around 100-200 mg.
  • Statins also impair the function of all sterols, including cholesterol and vitamin D (which is similar to cholesterol and is produced from cholesterol in your skin), all your sex hormones, cortisone, the dolichols, which are involved in keeping the membranes inside your cells healthy
  • Odds are greater than 100 to 1 that if you’re taking a statin, you don’t really need it. The ONLY subgroup that might benefit are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol.
  • Statins are in fact classified as a “pregnancy Category X medication”iv; meaning, it causes serious birth defects, and should NEVER be used by a woman who is pregnant or planning a pregnancy.

Parents Beware: Outrageous Push to Put Kids on Statin Drugs!

In a bold attempt to increase profits before the patent runs out, Pfizer has  introduced a chewable kid-friendly version of Lipitor. Its US patent for Lipitor expired in November 2011, and seeking to boost sales of the drug, children have become the new target market, and the conventional medical establishment is more than happy to oblige.

Researchers and many doctors are now calling for universal school screening of children to check for high cholesterol, to find those “in need of treatment.” In addition, older siblings, parents and other family members might be prompted to get screened as well, the researchers say, which would uncover additional, previously undiagnosed adults in need of the drug.

This is clearly NOT the way to improve public health. On the contrary, it could produce a new, massive wave of extremely dire health consequences in just a few years time.

So rather than improving school lunches, which would cost about a dollar a day per child, they’d rather “invest” ten times that for tests and drugs that in no way, shape, or form address the root cause, which is an improper, unhealthy diet! All they’re doing is allowing all the industries to maintain or increase their profits: Big Pharma; Big Sugar; Big Corn and the processed food industry.

Who pays?

You, and your children! And in far more ways than one!

Why Covid Vaccine Was Suspended – Paul Ehrlich Institute, Germany – Cerebral Vein Thrombosis

Germany’s medicine regulator, the Paul Ehrlich Institute, published a detailed FAQ to explain its controversial actions and recommendations:

‘A specific form of severe cerebral venous thrombosis associated with platelet deficiency (thrombocytopenia) and bleeding has been identified in seven cases (as of March 15th 2021) in temporal association with vaccination with COVID-19 Vaccine AstraZeneca.

‘(1) It is a very serious disease that is also difficult to treat. Of the seven affected individuals, three individuals had died.

‘(2) The affected individuals had ages ranging from about 20 to 50 years.

‘(3) Six of the affected persons had a particular form of cerebral venous thrombosis, called sinus vein thrombosis. All six individuals were younger to middle-aged women (see above). Another case with cerebral haemorrhage in platelet deficiency and thrombosis was medically very comparable. All cases occurred between four and 16 days after vaccination with COVID-19 Vaccine AstraZeneca. This presented as a comparable pattern.

‘(4) The number of these cases after vaccination with COVID-19 AstraZeneca is statistically significantly higher than the number of cerebral venous thromboses that normally occur in the unvaccinated population. For this purpose, an observed-versus-expected analysis was performed, comparing the number of cases expected without vaccination in a 14-day time window with the number of cases reported after approximately 1.6 million AstraZeneca vaccinations in Germany. About one case would have been expected, and seven cases had been reported.

‘(5) The younger to middle-aged population affected by the severe cerebral venous thrombosis with platelet deficiency is not the population at high risk for a severe or even fatal COVID-19 course.

‘(6) In addition to the experts from the Paul Ehrlich Institute, other experts in thrombosis, haematology, and an adenovirus specialist were consulted with the details of the reported cases. All experts agreed unanimously that a pattern could be discerned here and that a connection between the reported above-mentioned diseases and the vaccination with COVID-19 Vaccine AstraZeneca was not implausible. After an overall review and consideration of the above facts, the Paul Ehrlich Institute recommended that vaccination with the COVID-19 Vaccine AstraZeneca be suspended in Germany as a precautionary measure in order to further analyse the cases. The German Federal Ministry of Health (BMG) has followed this recommendation. The Pharmacovigilance Risk Assessment Committee (PRAC) at the European Medicines Agency (EMA) will review during the week of March 15th 2021, whether and how the new findings affect the benefit-risk profile of COVID-19 AstraZeneca and the EU authorisation of the vaccine.

Hearty Counsel from Mother Lanka – Canticle of Thanksgiving to overcome sulphurous fumes of slander & vitriolic words

Hearty Counsel from Mother Lanka – Canticle of Thanksgiving to overcome sulphurous fumes of slander & vitriolic words    

Pro_27:9  Ointment and perfume rejoice the heart: so is the sweetness of a man’s friend by hearty counsel.

  1. We thank you for Sri Lanka the 126 rivers with potable water in Sri Lanka
  2. We thank you for all you natural Goodness to our nation
  3. We repent of our deep divisions & uncaring attitudes & insensitivities to others’ hurts
  4. We thank you for amazing ocean resources & our splendid beaches north to south & west to east
  5. We thank you for amazing landscape & green isle
  6. We thank you for every hectare that produces golden harvest
  7. We thank you for Sri Lanka for all her ethnic peoples – majority will be the caring elder brother to all minorities
  8. We thank you for Sri Lanka with all its talented skilled people & their bonhomie & hospitality
  9. We thank you for Sri Lanka & her people famed for skill, arts, crafts, music & dance from ancient times
  10. We thank you for Sri Lanka for all her earning sources & resources – that give us avenues of livelihoods
  11. We thank you for Sri Lanka’s excellent education & health systems
  12. We thank you for lifelong covenants & friendships we have made across diverse backgrounds. Land like no other in the best sense of the word

Litany of Repentance Forgiveness for Reprieve & Reconciliation

  1. I ask you for Forgiveness for vitriolic words when I attacked the other side
  2. I ask you for Forgiveness for our deep divisions & uncaring attitudes & insensitivities to others’ hurts
  3. I ask you for Forgiveness for failing as a benefactor in my chosen field & my professional skill made money for myself at the cost of the beneficiary
  4. I ask you for Forgiveness for instances when I practised survival of the fittest & struggle for existence in the corporate
  5. I ask you for Forgiveness for growling like a bear when the other was weak, vulnerable, junior, powerless, hapless
  6. I ask you for Forgiveness for slander I originated or circulated as I chose to grind the axe & not bury the hatchet.
  7. I ask you for Forgiveness for choices, mindsets, partialities, prejudices & comments based on racism, sexism, casteism, regionalism, nepotism, religion.
  8. I ask you for Forgiveness for not identifying with the agony of the other race when they suffered & worst still, being proactive in harassment of the other race & being silent about the evil perpetrations of my race.
  9. I ask you for Forgiveness for my part in economic, social, sexual, pecuniary exploitation of the vulnerable & for my part in widening the rich poor gap.
  10. I ask you for Forgiveness for bad mouthing my nation, forsaking her in her hour of need and for thinking race above nationhood.
  11. I ask you for Forgiveness for not being a father figure role model in my field & for my part for making people destitute morally, financially, socially.
  12. I ask you for Forgiveness for abdicating Sri Lanka for greener pastures

Demand over Supply. Harvest in Jeopardy – Sow, Reap, Reward, Satisfaction

A Great God reprieve happened to the world after the devastation of WW II. Nations arose to good hope & prosperity by 1970. Every prospect seemed pleasing for each nation, to play their part in the family of nations, with many nations shaking off the “Colonial Yoke”, quite sure they will do better for themselves than when under Europeans. The West gave up on God for they said, we can do better than God could. What went wrong?

  1. Trampled Hearts like Roadside – relationships soured & kids’ hearts were abused & trampled by neglect – many passing influences. Good seeds were trampled by invading influences – rapid taste & see. Change is chic – digital screen was their post powerful mentor.  
  2. Ravens cackling in the air – conflict, garbage recycling, much ado for nothing, greed, squabbles – ravens pluck out good vision. How much envisioning they need.
  3. Stony hearts beneath, covered by spurious soft façade on the surface – perform or perish generation, swim or sink is what they heard. Roots & relationships are shallow, rupture often, frustration that nothing grows large or lasting. Much exhibition in the branches with shallow roots & no lasting fruit or relationships. Tragedy of  attention deficit – how much bonding they need.
  4. Thorns of non essentials – customer is king generation became the guinea pig of the market revolution. Personal to global – brands causing consumerist extravaganza overruns the world’s economy – poor impoverished, 99% of global GDP serving the super rich global oligarchy of 1%. Thorns that submerged fruit – Armament, motor industry, fashion, entertainment  hospitality & sex industry,  cosmetics, confectionaries, IT, toys, Pharmaceuticals, wellness illness industry overrun the economies. Covid accentuated the divide – giant caterpillars who eat the world.
  5. Remnant plying noble heart & good & lasting fruit – are they under siege to succumb to the drive of the age. Rage on stage.  

Lord of the Harvest – Harvest of Life – is it happenstance, coincidence or Destiny.  

  1. When Life is a Harvest – seed begets fruit. Sow & Reap is universal law.
  2. Story may have to begin with mom & dad supplying sperm & ovum to fertilize, conceive – baby born
  3. God thinks the baby is the most important fruit or harvest for any two. God keeps the world running for the next baby to be born
  4. Womb tine is first season of life. If Life is a tree, how we are conceived & early germination has influence over growth. Attend on womb time – as carefully as you can
  5. God moves from season to season – sowing to sowing. What you lose in one season is difficult to catch up – without supernatural help.
  6. One Seed bag is all that you get for life – do not lose any of the seed. Some seeds may be one for life time. Even your virginal purity- boy or girl is to be an investment for life long covenant. Sexual contact marks forever. Do not be causal. The sexual mark cuts deep – do so only in one faithful  lifelong covenant.
  7. Here is the equation – Seed, Time, Place, Space, Relationships, Opportunity, Harvest
  8. I consider all of life is a seed from God = Call of God.
  9. Are you the lord of your life or is there a Lord of the Harvest?
  10. Lord of the Harvest coordinates all the fields of human enterprise & the saying man’s extremity is God’s opportunity- to steer the course God’s Way for our best.  
  11. Parable of the Sower
  12. Is there a Lord of the Harvest or is all happenstance, coincidence or enemy action?